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Metabolite inhibition model

From: Yung-Wei Hsu <hsumd>
Date: Fri, 19 Sep 2008 12:34:29 +0800

Dear All,

 

I am working on lidocaine PK data from 106 patients receiving infusion for =
48 hours. The metabolite (MEGX) will decrease the clearance of the parent d=
rug (lidocaine). Therefore, I analyzed the data with nonlinear PK model (AD=
VAN6 TOL=3). I am wondering whether there is any metabolite inhibition mo=
del to analyze the lidocaine PK.

 

Any comment or suggestion will be highly appreciated.

 

Yung-Wei Hsu

Mackay Memorial Hospital

Taipei, Taiwan

+++++++++++++++++

$SUBROUTINE ADVAN6 TOL=3

$MODEL COMP (ONE) COMP (TWO)

$PK

V1= THETA(1)*EXP(ETA(1))

VMAX=THETA(2)*EXP(ETA(2))

KM=THETA(3)*EXP(ETA(3))

V2= THETA(4)*EXP(ETA(4))

Q2=THETA(5)*EXP(ETA(5))

$DES

DC1=A(1)/V1

DC2=A(2)/V2

CL=VMAX*DC1/(KM+DC1)

DADT(1)=Q2*DC2−(Q2+ CL)*DC1

DADT(2)=Q2*(DC1−DC2)

$ERROR

C1=A(1)/V1

Y=C1*(1+ERR(1))

IPRED=Y

++++++++++++++++++++++++++++++++++++++++++

 

 


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Received on Fri Sep 19 2008 - 00:34:29 EDT

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