NONMEM Users Network Archive

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Scaling for pediatric study planning

From: Joachim.Grevel
Date: Fri, 19 Sep 2008 15:06:05 +0200

Dear NM_Users,

we have all been good students and listened to Nick when he told us again
and again the rock-solid truths of allometry:

Volume: *(WT/70)

CL: *(WT/70)**0.75

any rate constant related to distribution or elimination:
*(WT/70)**(-0.25)

Here my questions:
a) how do we allometrically scale a first-order rate constant of
absorption after oral dosing?

b) how do we allometrically scale a first-order rate constant of
absorption from a subcutaneous injection site?

Thank you for your thoughts,

Joachim

__________________________________________
Joachim GREVEL, Ph.D.
MERCK SERONO International S.A.
Exploratory Medicine
1202 Geneva
Tel: +41.22.414.4751
Fax: +41.22.414.3059
Email: joachim.grevel




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Received on Fri Sep 19 2008 - 09:06:05 EDT

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