NONMEM Users Network Archive

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dataset codification

From: Mark Gutierrez <markgutierrez977>
Date: Wed, 24 Sep 2008 09:18:31 +0000 (GMT)

Dear all,   I am modeling some PK data from one rabbit. And I have=
 some doubts how to codify the dataset. The rabbit received different singl=
e doses of a drug at different times.   E.g, First of May it re=
ceived a 100 mg dose i.v. , Then, 2 months latter (enough washout period=
), the first of July, it received and oral dose of 100mg. Finally, after =
other two months the rabbit received the last oral dose 200mg.   I=
 could codify in the TIME column the real times, including the jumps of two=
 months, but I think that there is an option in Nonmem to “res=
tart” the dose through the dataset.     Could somebod=
y clarify me this point? and perhaps include a simple example of dataset.=
Received on Wed Sep 24 2008 - 05:18:31 EDT

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