NONMEM Users Network Archive

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Re: dataset codification

From: Sébastien Bihorel <sbihorel>
Date: Wed, 24 Sep 2008 05:52:21 -0400

Dear Mark,

You may want to read about "EVID" in the html help. EVID = 4 is what you
mean. It is a dosing event but implies that the system is reset before
the dose is introduced into the system.

Sebastien

Mark Gutierrez a écrit :
>
> Dear all,
>
>
>
> I am modeling some PK data from one rabbit. And I have some doubts how
> to codify the dataset. The rabbit received different single doses of a
> drug at different times.
>
>
>
> E.g,
>
> First of May it received a 100 mg dose i.v. ,
>
> Then, 2 months latter (enough washout period), the first of July, it
> received and oral dose of 100mg..
>
> Finally, after other two months the rabbit received the last oral dose
> 200mg.
>
>
>
> I could codify in the TIME column the real times, including the jumps
> of two months, but I think that there is an option in Nonmem to
> “restart” the dose through the dataset.
>
>
>
> Could somebody clarify me this point? and perhaps include a simple
> example of dataset.
>
>
>
> Thank you in advance
>
> Mark
>
>

Received on Wed Sep 24 2008 - 05:52:21 EDT

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