NONMEM Users Network Archive

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RE: dataset codification

From: Willavize, Susan A <susan.a.willavize>
Date: Wed, 24 Sep 2008 12:17:14 -0400

I have seen EVID=4 used, but don't remember the details. How does the =
time variable look? I always convert Date and time to a time counting =
variable that starts at 0 time (time of first dose) and always increases =
within each subject. I recall that when EVID= 4 is used, the time =
variable does NOT need to restart with the second dose. Do I remember =
correctly?

 

 

Note I do not include DATE and clock TIME in my NONMEM input, since I =
have seen NONMEM do nefarious things with these.

 

Susan

________________________________

From: owner-nmusers
On Behalf Of Sbastien Bihorel
Sent: Wednesday, September 24, 2008 5:52 AM
To: Mark Gutierrez
Cc: nmusers
Subject: Re: [NMusers] dataset codification

 

Dear Mark,

You may want to read about "EVID" in the html help. EVID = 4 is what =
you mean. It is a dosing event but implies that the system is reset =
before the dose is introduced into the system.

Sebastien

Mark Gutierrez a crit :

Dear all,

 

I am modeling some PK data from one rabbit. And I have some doubts how =
to codify the dataset. The rabbit received different single doses of a =
drug at different times.

 

E.g,

First of May it received a 100 mg dose i.v. ,

Then, 2 months latter (enough washout period), the first of July, it =
received and oral dose of 100mg..

Finally, after other two months the rabbit received the last oral dose =
200mg.

 

I could codify in the TIME column the real times, including the jumps of =
two months, but I think that there is an option in Nonmem to "restart" =
the dose through the dataset.

 

Could somebody clarify me this point? and perhaps include a simple =
example of dataset.

 

Thank you in advance

Mark

 


Received on Wed Sep 24 2008 - 12:17:14 EDT

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