NONMEM Users Network Archive

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Re: dataset codification

From: Sébastien Bihorel <sbihorel>
Date: Wed, 24 Sep 2008 13:03:43 -0400

You are right Susan: the Time values have to increase within a subject.
Using EVID=4 allows you to use a more convenient time scale
ex:

ID TIME EVID...
1 0 1
1 1 0
... ... ...
1 24 4
... ... ...

instead of

ID TIME EVID...
1 0 1
1 1 0
... ... ...
1 26546 1
... ... ...

Assuming you don't have any measurement after 24h during the first
period of your study.

Willavize, Susan A a crit :
>
> I have seen EVID=4 used, but don't remember the details. How does the
> time variable look? I always convert Date and time to a time counting
> variable that starts at 0 time (time of first dose) and always
> increases within each subject. I recall that when EVID= 4 is used,
> the time variable does NOT need to restart with the second dose. Do I
> remember correctly?
>
>
>
>
>
> Note I do not include DATE and clock TIME in my NONMEM input, since I
> have seen NONMEM do nefarious things with these.
>
>
>
> Susan
>
> ------------------------------------------------------------------------
>
> *From:* owner-nmusers
> [mailto:owner-nmusers
> *Sent:* Wednesday, September 24, 2008 5:52 AM
> *To:* Mark Gutierrez
> *Cc:* nmusers
> *Subject:* Re: [NMusers] dataset codification
>
>
>
> Dear Mark,
>
> You may want to read about "EVID" in the html help. EVID = 4 is what
> you mean. It is a dosing event but implies that the system is reset
> before the dose is introduced into the system.
>
> Sebastien
>
> Mark Gutierrez a crit :
>
> Dear all,
>
>
>
> I am modeling some PK data from one rabbit. And I have some doubts how
> to codify the dataset. The rabbit received different single doses of a
> drug at different times.
>
>
>
> E.g,
>
> First of May it received a 100 mg dose i.v. ,
>
> Then, 2 months latter (enough washout period), the first of July, it
> received and oral dose of 100mg..
>
> Finally, after other two months the rabbit received the last oral dose
> 200mg.
>
>
>
> I could codify in the TIME column the real times, including the jumps
> of two months, but I think that there is an option in Nonmem to
> "restart" the dose through the dataset.
>
>
>
> Could somebody clarify me this point? and perhaps include a simple
> example of dataset.
>
>
>
> Thank you in advance
>
> Mark
>
>
>

Received on Wed Sep 24 2008 - 13:03:43 EDT

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