Susan,
NM-TRAN's translation of DATE and TIME is a critical part of the system.
If you have found a problem then I encourage you to report the details
to nmconsult <nmconsult
Willavize, Susan A wrote:
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> Note I do not include DATE and clock TIME in my NONMEM input, since I
> have seen NONMEM do nefarious things with these.
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Sebastian,
Sébastien Bihorel wrote:
> You are right Susan: the Time values have to increase within a
> subject. Using EVID=4 allows you to use a more convenient time scale
>
In general I try to avoid using EVID=4 because it requires the
assumption of complete washout from previous doses. The convenience of
every dose starting at time zero may be offset by the inconvenience of
getting the wrong parameter estimates.
Nick
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
Received on Wed Sep 24 2008 - 15:40:50 EDT
