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Re: a potential bug

From: Leonid Gibiansky <LGibiansky>
Date: Mon, 29 Sep 2008 17:02:03 -0400

It is hard to tell what is going one without seeing the data file. The
first idea is that RATE is incorrectly computed (e.g., incorrect time
The controls stream and the data files with 1 dose and few observed data
points would allow to check it.

Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
e-mail: LGibiansky at
tel: (301) 767 5566

> Hello NONMEM Users,
> Subjects received IV infusion (study 2), IV injection or SQ injection
> (study1). In addition, I had to inject a dummy (amt=1) dose into the
> 3^rd compartment, which describes the target. 2 studies were
> integrated. The time-concentration plots looked good for one study (IV
> injection or SC infusion) and meaningless/really bad for the other one
> (IV infusion; population-predicted values were a few-fold different
> from the observed ones). The data look correct. The rate, dose, and
> times look fine (rate=amt/infusion_duration; the first measure is taken
> after the end off infusion). When I set Rate=0 for the second study,
> the outcome looks perfect for both studies; the objective function
> decreased a lot. Because I do not feel comfortable using Rate=0, I
> tried to change the order of the dummy and real doses, set time of the
> real dose to 1 second, etc. Nothing works. It looks like a NONMEM bug.
> Thank you,
> Pavel
Received on Mon Sep 29 2008 - 17:02:03 EDT

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