NONMEM Users Network Archive

Hosted by Cognigen

9th Fisher/Shafer NONMEM/PLT Tools Workshop

From: Steven Shafer <steven.shafer>
Date: Wed, 1 Apr 2009 10:56:23 -0700

Dear Colleagues:


There are a few seats still available for the 9th Fisher / Shafer NONMEM
Workshop, which is just 5 weeks away. We do not plan on offering another
course in North America this year, so if you are interested in taking this
advanced NONMEM course in the US this year, you need to sign up soon. The
course will be held in Bethesda, Maryland from Wednesday, May 6th, through
Sunday, May 10th. You can see the course description and registration
details at


Our NONMEM Workshops are now in their 5th year. Dennis Fisher and I have
spent the past two years developing PLT Tools, which has now completed its
first year of testing. For the 9th Fisher/Shafer NONMEM course we have
completed converted from the R scripts and Windows batch commands offered in
our previous courses to the substantially more capable PLT Tools platform.


You can download the completely functional non-licensed version of PLT Tools
from Even if you don't install it, you should look at the
user interface. Model validation is facilitated with automated procedures
for visual predictive checks, log likelihood profiling, jack-knife analysis,
and extensive bootstrap analysis for determination of standard errors. We
are also including a robust library of control streams and a control stream
editor. CFR 11 Part 22 compliance is built into the program, as is extensive
run archiving and creation of audit trails. PLT Tools also includes a
comprehensive set of graphical and statistical analyses facilitate model
development and testing. A sample output can be downloaded from The licensed version of PLT Tools supports distributing
NONMEM processing across networked computers.


One of the joys of teaching this course is the considerable evolution in
course material every time the workshop is offered. Dennis and I continuous
update the course materials, based both on feedback from course participants
and our own exploration of novel pharmacometric problems. Now that we have
converted our own work entirely to the PLT Tools platform, we think course
participants will similarly benefit from a simple interface that provides
outstanding diagnostic graphics, and automates advanced tasks including VPC,
LL profiles, and bootstrap analysis.


We hope to see you in Bethesda!




Steven L. Shafer, MD

Professor of Anesthesiology, Columbia University

Adjunct Professor of Anesthesia, Stanford University

Adjunct Professor of Biopharmaceutical Sciences, UCSF

Editor-in-Chief, Anesthesia & Analgesia


Received on Wed Apr 01 2009 - 13:56:23 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: