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Re: Indirect response model question

From: nidal.alhuniti
Date: Fri, 3 Apr 2009 18:03:21 -0400

Hi Shen,

The short answer is yes, under $PK you could fit a linear spline through the
observed conc. and use it in $DES.

Ex.



$PK

   IF(NEWIND.NE.2) THEN

    LCP=0

    LTM=TIME

   ENDIF



   INT = LCP

   TINT = LTM

   DEN = TIME-TINT



   IF(DEN.EQ.0) THEN

     SLOP = 0

     ELSE

     SLOP = (CP-INT)/DEN

   ENDIF

   LCP=CP

   LTM=TIME



$DES

   INPUT=INT+SLOP*(T-TINT) ;INPUT IS INTERPOLATED CP





Best,

Nidal



Nidal AL-Huniti, PhD

Associate Director, Modeling and Simulations

ICON Development Solutions SM




On 4/3/09, Shen Li <shen99
>
> Dear all,
>
> Can an indirect response model be used for PD modeling alone in NONMEM
> (without PK modeling)? I am planning to evaluate the concentration-response
> relationship for a PD marker. I am wondering whether I can just use the
> observed PK concentrations in the indirect response model in NONMEM.
>
> Thanks!
> Shen
>

Received on Fri Apr 03 2009 - 18:03:21 EDT

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