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Re: When is F1 Evaluated

From: Nick Holford <n.holford>
Date: Fri, 10 Apr 2009 21:52:21 +0200

Bill,

F1 is evaluated at the instant that AMT enters CMT=1.

If you want to modify F during absorption you will need to use something
like this:

$DES
DADT(1) = -KA*A(1) ; gut loss (F1 will affect the AMT entering this CMT
at the time of AMT record)
FT=a+ b*A(1) ; some function of amount in CMT=1
DADT(2) = FT*KA*A(1) - CL*A(2)/V ; FT is a time varying fraction of the
rate entering CMT=2

Nick

Denney, William S. wrote:
>
> Hello,
>
> When is F1 evaluated? I am working on a model with nonlinear
> bioavailability and I need to know if F1 is evaluated during the
> entire absorption process or if it is evaluated upon the dose entering
> the dosing compartment.
>
> Thanks,
>
> Bill
>
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--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
mobile: +33 64 271-6369 (Apr 6-Jul 17 2009)
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford

Received on Fri Apr 10 2009 - 15:52:21 EDT

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