NONMEM Users Network Archive

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Re: Imaginary concentrations

From: Nick Holford <n.holford>
Date: Mon, 13 Apr 2009 17:55:12 +0200

Hi,

The OFV is computed using all observations. If you imagine an
observation at time 0 then it will change the OFV. So my advice is not
to imagine concentrations with MDV=0 but just use the concentrations you
really measured.

Nick

ke fang wrote:
> Hi!
> Dear all!
> My samples were collected after a single intramuscular injection. One individuals provies only one tissue samples within the whole study. I found the MOFV were quite different between the MDV was used or not.
>
> In my opinion, the concentration in tissue at T0 must be 0 because of the intramuscular administration. So the concentration at T0 was not a real observed 0 but a assumed 0. The question was that if i treated the T0 concentration as a MDV, the MOFV was quite different from treating it as a real obesrved concentration.
>
> Whether the MDV should be used in my case? Can anyone help me with this problem?
>
> Thanks in advance!
>
>
> Fang Ke
>
>
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--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
n.holford
mobile: +33 64 271-6369 (Apr 6-Jul 17 2009)
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford

Received on Mon Apr 13 2009 - 11:55:12 EDT

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