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Re: Re: Imaginary concentrations

From: ke fang <fang.coco>
Date: Tue, 14 Apr 2009 14:19:13 +0800 (CST)




--- On Mon, 4/13/09, Nick Holford <n.holford

> From: Nick Holford <n.holford
> Subject: [NMusers] Re: Imaginary concentrations
> To: nmusers
> Date: Monday, April 13, 2009, 11:55 PM
> Hi,
>
> The OFV is computed using all observations. If you imagine
> an
> observation at time 0 then it will change the OFV. So my
> advice is not
> to imagine concentrations with MDV=0 but just use the
> concentrations you
> really measured.
>
> Nick
>
> ke fang wrote:
> > Hi!
> > Dear all!
> > My samples were collected after a single intramuscular
> injection. One individuals provies only one tissue samples
> within the whole study. I found the MOFV were quite
> different between the MDV was used or not.
> > 
> > In my opinion, the concentration in tissue at T0 must
> be 0 because of the intramuscular administration. So the
> concentration at T0 was not a real observed 0 but a assumed
> 0. The question was that if i treated the T0 concentration
> as a MDV, the MOFV was quite different from treating it as a
> real obesrved concentration.
> > 
> > Whether the MDV should be used in my case? Can anyone
> help me with this problem?
> > 
> > Thanks in advance!
> > 
> > 
> > Fang Ke
> >
> >
> >   
> >   
>
> --
> Nick Holford, Dept Pharmacology & Clinical
> Pharmacology
> University of Auckland, 85 Park Rd, Private Bag 92019,
> Auckland, New Zealand
> n.holford
> tel:+64(9)923-6730 fax:+64(9)373-7090
> mobile: +33 64 271-6369 (Apr 6-Jul 17 2009)
> http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
>
>
>

Thanks to all!

I've go thourgh the guide book of NONMEM and found the EVID term could sepe=
rate the dose from observation event. So i need not to use the MDV term. =
Received on Tue Apr 14 2009 - 02:19:13 EDT

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