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RE: VPC with Mixture Model

From: Mats Karlsson <mats.karlsson>
Date: Tue, 14 Apr 2009 19:53:51 +0200

Dear Satyendra,


Interesting question. I don't think there is much written about this, but I
may be wrong. What I would not do is to try to stratify based on estimated
subpopulation allocation ("EST"). Rather I would use the same VPCs as if
there had been no mixture model. Possibly what you could do is be more
careful in your choice of prediction intervals to display. For example, if
you have a subpopulation of poor metabolizers of about 5%, displaying only
median and interquartile range PIs may not be a good idea.


Best regards,



Mats Karlsson, PhD

Professor of Pharmacometrics

Dept of Pharmaceutical Biosciences

Uppsala University

Box 591

751 24 Uppsala Sweden

phone: +46 18 4714105

fax: +46 18 471 4003


From: owner-nmusers
Behalf Of Satyendra Suryawanshi
Sent: Tuesday, April 14, 2009 6:50 PM
To: nmusers
Subject: [NMusers] VPC with Mixture Model


Dear all,

I have a Mixture Model with 2 subpopulation. Now I want to check its
prediction. One way to see this is a Visual Predictive Check. My question
is, How to perform visual predictive check with mixture model?

I will be thankful for your suggestion and references.


Best regards


Satyendra Suryawanshi, PhD

University of Tennessee Health Science Center


Received on Tue Apr 14 2009 - 13:53:51 EDT

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