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RE: Resetting af single compartment

From: Elassaiss - Schaap, J. <jeroen.elassaiss>
Date: Thu, 23 Apr 2009 16:54:56 +0200

 
Thomas,
 
Two solutions (their smart scale is up to you to judge ;-):
 
1 - rewrite the model so you don't need the changepoint (best approach =
IMHO)
 
2 - I guess you could switch the model to a different differential =
equation instead
e.g.
   CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
   DADT(3) = SLCT*CHNG
   DADT(4) = (1-SLCT)*CHNG
But I have not tested that approach. I guess it should work.
 
Best regards,
Jeroen

Jeroen Elassaiss-Schaap, PhD
Modeling & Simulation Expert
Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
Early Clinical Research and Experimental Medicine
Schering-Plough Research Institute
T: +31 41266 9320

 

  _____

From: owner-nmusers
On Behalf Of TKT (Thomas Klitgaard)
Sent: Thursday, 23 April, 2009 15:20
To: nmusers
Subject: [NMusers] Resetting af single compartment


Dear all
 
I need to reset a single compartment in a model of several cmts, without =
resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
 
Thanks,
Thomas
 
 
____________________

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Principal Scientist
Biomodelling

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+45 3079 4960 (mobile)
tkt
www.novonordisk.com

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Received on Thu Apr 23 2009 - 10:54:56 EDT

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