NONMEM Users Network Archive

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RE: Resetting af single compartment

From: Elassaiss - Schaap, J. <jeroen.elassaiss>
Date: Thu, 23 Apr 2009 16:54:56 +0200

Two solutions (their smart scale is up to you to judge ;-):
1 - rewrite the model so you don't need the changepoint (best approach =
2 - I guess you could switch the model to a different differential =
equation instead
   CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
   DADT(4) = (1-SLCT)*CHNG
But I have not tested that approach. I guess it should work.
Best regards,

Jeroen Elassaiss-Schaap, PhD
Modeling & Simulation Expert
Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
Early Clinical Research and Experimental Medicine
Schering-Plough Research Institute
T: +31 41266 9320



From: owner-nmusers
On Behalf Of TKT (Thomas Klitgaard)
Sent: Thursday, 23 April, 2009 15:20
To: nmusers
Subject: [NMusers] Resetting af single compartment

Dear all
I need to reset a single compartment in a model of several cmts, without =
resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?

Thomas Klitgaard
Principal Scientist

Novo Nordisk A/S
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Received on Thu Apr 23 2009 - 10:54:56 EDT

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