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Re: Resetting af single compartment

From: Leonid Gibiansky <LGibiansky>
Date: Thu, 23 Apr 2009 11:39:41 -0400

 From the NM help for CMT data item:

  Other-Type Event:
       A positive value of CMT specifies a compartment to be turned on.
       A negative value of CMT specifies a compartment to be turned off.

So my guess is that

  EVID CMT
   2 -3
   2 3

Should reset this particular compartment 3 (although I never tried it)
Leonid


--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566




Elassaiss - Schaap, J. (Jeroen) wrote:
>
> Thomas,
>
> Two solutions (their smart scale is up to you to judge ;-):
>
> 1 - rewrite the model so you don't need the changepoint (best approach IMHO)
>
> 2 - I guess you could switch the model to a different differential
> equation instead
> e.g.
> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> DADT(3) = SLCT*CHNG
> DADT(4) = (1-SLCT)*CHNG
> But I have not tested that approach. I guess it should work.
>
> Best regards,
> Jeroen
>
> *Jeroen Elassaiss-Schaap, PhD*
> Modeling & Simulation Expert
> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> Early Clinical Research and Experimental Medicine
> Schering-Plough Research Institute
> T: +31 41266 9320
>
>
>
> ------------------------------------------------------------------------
> *From:* owner-nmusers
> [mailto:owner-nmusers
> *Sent:* Thursday, 23 April, 2009 15:20
> *To:* nmusers
> *Subject:* [NMusers] Resetting af single compartment
>
> Dear all
>
> I need to reset a single compartment in a model of several cmts, without
> resetting the whole system for the
> subject (which EVID=4 would do). Is there a *smart* way to do this?
>
> Thanks,
> Thomas
>
>
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Received on Thu Apr 23 2009 - 11:39:41 EDT

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