NONMEM Users Network Archive

Hosted by Cognigen

RE: Resetting af single compartment

From: Bachman, William <William.Bachman>
Date: Thu, 23 Apr 2009 12:05:08 -0400

I have not tried it either, but, I think this would not reset the =
amounts in these compartments. I believe it would retain the value when =
turned off until turned back on.

-----Original Message-----
From: owner-nmusers
On Behalf Of Leonid Gibiansky
Sent: Thursday, April 23, 2009 11:40 AM
To: Elassaiss - Schaap, J. (Jeroen)
Cc: nmusers
Subject: Re: [NMusers] Resetting af single compartment


 From the NM help for CMT data item:

  Other-Type Event:
       A positive value of CMT specifies a compartment to be turned on.
       A negative value of CMT specifies a compartment to be turned off.

So my guess is that

  EVID CMT
   2 -3
   2 3

Should reset this particular compartment 3 (although I never tried it)
Leonid


--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566




Elassaiss - Schaap, J. (Jeroen) wrote:
>
> Thomas,
>
> Two solutions (their smart scale is up to you to judge ;-):
>
> 1 - rewrite the model so you don't need the changepoint (best approach =
IMHO)
>
> 2 - I guess you could switch the model to a different differential
> equation instead
> e.g.
> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> DADT(3) = SLCT*CHNG
> DADT(4) = (1-SLCT)*CHNG
> But I have not tested that approach. I guess it should work.
>
> Best regards,
> Jeroen
>
> *Jeroen Elassaiss-Schaap, PhD*
> Modeling & Simulation Expert
> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> Early Clinical Research and Experimental Medicine
> Schering-Plough Research Institute
> T: +31 41266 9320
>
>
>
> =
------------------------------------------------------------------------
> *From:* owner-nmusers
> [mailto:owner-nmusers
Klitgaard)
> *Sent:* Thursday, 23 April, 2009 15:20
> *To:* nmusers
> *Subject:* [NMusers] Resetting af single compartment
>
> Dear all
>
> I need to reset a single compartment in a model of several cmts, =
without
> resetting the whole system for the
> subject (which EVID=4 would do). Is there a *smart* way to do this?
>
> Thanks,
> Thomas
>
>
> ____________________
>
> *Thomas Klitgaard
> *Principal Scientist
> Biomodelling
>
> Novo Nordisk A/S
> Krogshøjvej 53 A
> DK-2880 Bagsværd
> Denmark
> +45 4442 4960 (direct)
> +45 3079 4960 (mobile)
> tkt
> _www.novonordisk.com_
>
> *Changing **possibilities in haemophilia
> *Did you know that 75% of people with haemophilia live in developing
> countries, and receive neither proper diagnosis nor adequate care and
> treatment? This reduces life expectancy down to just the teenage =
years.
> The Novo Nordisk Haemophilia Foundation supports 22 projects in the
> developing world to improve haemophilia care and treatment. _Learn =
more
> _
> =
<http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossib=
ilitiesActivities/HaemophiliaTreatment2.asp>
>
> This e-mail (including any attachments) is intended for the =
addressee(s)
> stated above only and may contain confidential information protected =
by
> law. You are hereby notified that any unauthorized reading, =
disclosure,
> copying or distribution of this e-mail or use of information contained =

> herein is strictly prohibited and may violate rights to proprietary
> information. If you are not an intended recipient, please return this
> e-mail to the sender and delete it immediately hereafter. Thank you.
>
>
> =
------------------------------------------------------------------------
> This message and any attachments are solely for the intended =
recipient.
> If you are not the intended recipient, disclosure, copying, use or
> distribution of the information included in this message is prohibited =

> --- Please immediately and permanently delete.
> =
------------------------------------------------------------------------
ICON plc made the following annotations.
-------------------------------------------------------------------------=
-----
This e-mail transmission may contain confidential or legally privileged i=
nformation
that is intended only for the individual or entity named in the e-mail ad=
dress. If you
are not the intended recipient, you are hereby notified that any disclosu=
re, copying,
distribution, or reliance upon the contents of this e-mail is strictly pr=
ohibited. If
you have received this e-mail transmission in error, please reply to the =
sender, so that
ICON plc can arrange for proper delivery, and then please delete the mess=
age.
Thank You,
ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835

Received on Thu Apr 23 2009 - 12:05:08 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.