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FW: Resetting af single compartment

From: Bachman, William <William.Bachman>
Date: Thu, 23 Apr 2009 14:31:53 -0400

One person who tests a hypothesis is worth 10 who speculate on the =
outcome!

Thanks to Leonid, Dick Brundage (who quoted chapter & verse from the =
NONMEM Manual), and to Mahesh. I stand corrected.

Bill

-----Original Message-----
From: Leonid Gibiansky [mailto:LGibiansky
Sent: Thursday, April 23, 2009 1:12 PM
To: Bachman, William
Subject: Re: [NMusers] Resetting af single compartment

it is working, I checked it, the amount is fixed to zero, not retained.
Best
Leonid




Bachman, William wrote:
> I have not tried it either, but, I think this would not reset the =
amounts in these compartments. I believe it would retain the value when =
turned off until turned back on.
>
> -----Original Message-----
> From: owner-nmusers
[mailto:owner-nmusers
> Sent: Thursday, April 23, 2009 11:40 AM
> To: Elassaiss - Schaap, J. (Jeroen)
> Cc: nmusers
> Subject: Re: [NMusers] Resetting af single compartment
>
>
> From the NM help for CMT data item:
>
> Other-Type Event:
> A positive value of CMT specifies a compartment to be turned =
on.
> A negative value of CMT specifies a compartment to be turned =
off.
>
> So my guess is that
>
> EVID CMT
> 2 -3
> 2 3
>
> Should reset this particular compartment 3 (although I never tried it)
> Leonid
>
>
> --------------------------------------
> Leonid Gibiansky, Ph.D.
> President, QuantPharm LLC
> web: www.quantpharm.com
> e-mail: LGibiansky at quantpharm.com
> tel: (301) 767 5566
>
>
>
>
> Elassaiss - Schaap, J. (Jeroen) wrote:
>>
>> Thomas,
>>
>> Two solutions (their smart scale is up to you to judge ;-):
>>
>> 1 - rewrite the model so you don't need the changepoint (best =
approach IMHO)
>>
>> 2 - I guess you could switch the model to a different differential
>> equation instead
>> e.g.
>> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
>> DADT(3) = SLCT*CHNG
>> DADT(4) = (1-SLCT)*CHNG
>> But I have not tested that approach. I guess it should work.
>>
>> Best regards,
>> Jeroen
>>
>> *Jeroen Elassaiss-Schaap, PhD*
>> Modeling & Simulation Expert
>> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
>> Early Clinical Research and Experimental Medicine
>> Schering-Plough Research Institute
>> T: +31 41266 9320
>>
>>
>>
>> =
------------------------------------------------------------------------
>> *From:* owner-nmusers
>> [mailto:owner-nmusers
Klitgaard)
>> *Sent:* Thursday, 23 April, 2009 15:20
>> *To:* nmusers
>> *Subject:* [NMusers] Resetting af single compartment
>>
>> Dear all
>>
>> I need to reset a single compartment in a model of several cmts, =
without
>> resetting the whole system for the
>> subject (which EVID=4 would do). Is there a *smart* way to do this?
>>
>> Thanks,
>> Thomas
>>
>>
>> ____________________
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>> *Principal Scientist
>> Biomodelling
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>> Novo Nordisk A/S
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Received on Thu Apr 23 2009 - 14:31:53 EDT

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