NONMEM Users Network Archive

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3-sites absorption model

From: Tremblay, Pierre-Olivier <potremblay>
Date: Mon, 27 Apr 2009 08:57:59 -0400

Dear NMusers,

I have a technical question, I wish to implement a linear 3 absorption
sites model in NONMEM. However, I'm not very familiar with the ADVAN5
to 9 subroutines (or should it even be coded using those?). Below is an
exerpt of the model in WinNonlin code, I was wondering if someone could
point me in the right direction with this or would have a reference for
a similar model.

TEMPORARY
DOSE=250000
END

START
Z(1) = 0
Z(2) = 0
END

DIFFERENTIAL
FR1=1-(FR2+FR3)
FR2=1-(FR1+FR3)
FR3=1-(FR1+FR2)
 
INPT1 = DOSE*FR1*KA1*EXP(-KA1*X)

 IF X LE TLAG1 THEN
 INPT2 = 0
ELSE
 INPT2 = DOSE*(1-FR1)*KA2*EXP(-KA2*(X-TLAG1))
ENDIF
 
IF X LE TLAG2 THEN
  INPT3 = 0
ELSE
  INPT3 = DOSE*FR3*KA3*EXP(-KA3*(X-TLAG2))
ENDIF
 
DZ(1) = (INPT1 + INPT2 + INPT3)/V - (KEL+K12)*Z(1)+K21*Z(2)
DZ(2) = K12*Z(1)-K21*Z(2)
 
END
 
FUNCTION 1
F= Z(1)
END

Many thanks in advance for your help !


Pierre-Olivier Tremblay

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Received on Mon Apr 27 2009 - 08:57:59 EDT

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