NONMEM Users Network Archive

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NONMEM and Dose calculation

From: Khaled Mohammed Abduljalil <kabdulja>
Date: Thu, 30 Apr 2009 11:16:33 +0200

Dear nmusers,

Could anyone tell me how i can predict the required dose
of a drug at steady state based on final sequential PK/PD
estimates from NONMEM.
If I assume for example a target PD value of INR is 2.5.
VKORC1 (and CYP2C9 polymorphism and AGE) affect PD (and
PK) profiles.

Thanks in advance
Best Regards
Received on Thu Apr 30 2009 - 05:16:33 EDT

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