NONMEM Users Network Archive

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covariate-based dose prediction

From: Khaled Nm <khal_nm>
Date: Thu, 30 Apr 2009 02:37:42 -0700 (PDT)

Dear nmusers,

Could anyone tell me how i can predict the required dose of a drug at steady state based on final sequential PK/PD estimates from NONMEM.
If I assume for example a target PD value of INR is 2.5. VKORC1 (and CYP2C9 polymorphism and AGE) affect PD (and PK) profiles.

Thanks in advance
Best Regards


Received on Thu Apr 30 2009 - 05:37:42 EDT

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