NONMEM Users Network Archive

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COND LAPLACE LIKELIHOOD

From: wangx826
Date: 04 Aug 2009 12:37:58 -0500

Dear nmusers,

Has anybody seen the following error message from NONMEM:
"CONDITIONAL LIKELIHOOD SET TO NEGATIVE VALUE
 WITH INDIVIDUAL 2 (IN INDIVIDUAL RECORD ORDERING), DATA RECORD 13"?
What does it mean?

I am trying to use conditional lapalacian likelihood method to generate a=
 
proportional odds model dealing with categorical PD data. Here is a little=
 
piece of my data set:
SUBJ TIME AMT EVID II ADDL DV CL V MDV
2 0 . 0 . . 0 4.12 63 0
2 0 1 1 1 20 . 4.12 63 1
2 0.005 . 2 . . . 4.12 63 1
2 0.01 . 2 . . . 4.12 63 1
.
.
.
2 12 . 0 . . 0 4.12 63 0
2 13 . 0 . . 1 4.12 63 0
.
.
.
But I don't think the problem exists in the data set because I tried
deleting the rows indicated in the error message, but the exactly same
message still came out and NONMEM stopped running. I have no idea what's
the problem for my model.

Thanks in advance,

Tianli
Received on Tue Aug 04 2009 - 13:37:58 EDT

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