From: Bill Gillespie <*billgillespie*>

Date: Fri, 7 Aug 2009 07:43:55 -0400

Hi Sherwin,

As Nick said, Alison would be the best source fro details, but I can

give you the basic idea of what's done. For the constant rate input

case, the solution is obtained as Nick described. In the case of

multiple dosing with equal doses and dosing intervals, it is a root-

finding problem that iteratively seeks a vector of values for the

initial amounts in the compartments. The solution is the set of values

such that the initial and final (end of dosing interval) values are

equal for all compartments.

Bill

On Aug 5, 2009, at 2:44 PM, Sherwin K Sy wrote:

*> Dear NONMEM users,
*

*>
*

*> I'm wondering what equation or ODE is used in NONMEM when the steady
*

*> state is set (i.e. SS = 1). Is it the case that the initial
*

*> parameter for the compartment is set to a different value? If so,
*

*> how does NONMEM set this value?
*

*>
*

*> I would appreciate if anyone can provide me with a reference or
*

*> point me to where I can find this information, including the type of
*

*> equation used for extravascular, iv bolus and iv infusion models.
*

*>
*

*> Thanks,
*

*>
*

*> Sherwin
*

*>
*

*>
*

Received on Fri Aug 07 2009 - 07:43:55 EDT

Date: Fri, 7 Aug 2009 07:43:55 -0400

Hi Sherwin,

As Nick said, Alison would be the best source fro details, but I can

give you the basic idea of what's done. For the constant rate input

case, the solution is obtained as Nick described. In the case of

multiple dosing with equal doses and dosing intervals, it is a root-

finding problem that iteratively seeks a vector of values for the

initial amounts in the compartments. The solution is the set of values

such that the initial and final (end of dosing interval) values are

equal for all compartments.

Bill

On Aug 5, 2009, at 2:44 PM, Sherwin K Sy wrote:

Received on Fri Aug 07 2009 - 07:43:55 EDT