NONMEM Users Network Archive

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dose non-proportional

From: Xiaolu Tao <tao>
Date: Mon, 10 Aug 2009 08:10:39 -0400

Dear NONMEM user,

This may be an old topic. I newly subscribed to the mail list and I searche=
d the archives, but could not find the related answer.

We have a compound, which showed a more-than-dose-proportional increase in =
SAD. The slope from power model was ~1.4, the half-life is consistent in al=
l the cohorts though. Also in MAD, the accumulation was less than expected.=
 Could you please kindly instruct me how to incorporate these two factors i=
n the NONMEM?

I really appreciate your help!


Received on Mon Aug 10 2009 - 08:10:39 EDT

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