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Asterisks in simulated data after changes to maximum observation records and BUFFER

From: Paul Hutson <prhutson>
Date: Thu, 13 Aug 2009 12:07:28 -0500
I am attempting to generate 100 iterations of a concentration curve for multiple doses in a single individual.
In order to reflect the input of the extended release dosage form from the dissolution data, I have multiple infusions into the gut representing the amount released in each of these units of time based on the dissolution data.  For 14 doses, then, I am reproducing this, and the data file is quite long (687 records).  I have therefore had to increase NSIZES with respect to the number of observations, as well as increasing buffers 1,2, and 6.

I will need to import the results into R, since excel can't take 687X100 lines of output.  However, regardless of whether I look at my .txt output, or importing it as far as I can into Excel, the output includes asterisks
ID  TIME CMPT IPRE DV PRED RES WRES
  1.0000E+00  0.0000E+00  1.0000E+00  0.0000E+00  0.0000E+00  0.0000E+00  0.0000E+00  0.0000E+00
  1.0000E+00  2.5000E-01  2.0000E+00  1.1193E-05 -5.6330E-02  3.0897E-05 -5.6361E-02  0.0000E+00
  1.0000E+00  2.5000E-01  3.0000E+00  3.6747E-09  3.6747E-09  1.0143E-08 -6.4683E-09  0.0000E+00
  1.0000E+00  2.5000E-01  1.0000E+00  1.1193E-05  0.0000E+00  3.0897E-05  0.0000E+00  0.0000E+00
  1.0000E+00  5.0000E-01  2.0000E+00 *********** *********** *********** ***********  0.0000E+00
  1.0000E+00  5.0000E-01  3.0000E+00 *********** *********** *********** ***********  0.0000E+00

Can anyone explain why I am getting the asterisks in the output (even with only one simulation?  Everything was fine before I  messed with the buffers  (relevant part of SIZES below):
C NO: MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD
C IF NO IS CHANGED, ALSO RECOMPILE NM-TRAN, NM-TRAN LIBRARY
      PARAMETER (NO=750)
...
C LIM1: SIZE OF BUFFER 1
      PARAMETER (LIM1=800)
C LIM2: SIZE OF BUFFER 2
      PARAMETER (LIM2=800)
C LIM3: SIZE OF BUFFER 3
      PARAMETER (LIM3=200)
C LIM4: SIZE OF BUFFER 4
      PARAMETER (LIM4=50)
C LIM5: SIZE OF BUFFER 5
      PARAMETER (LIM5=200)
C LIM6: SIZE OF BUFFER 6
      PARAMETER (LIM6=800)
C LIM7: SIZE OF BUFFER 7
      PARAMETER (LIM7=2)
C LIM8: SIZE OF BUFFER 8
      PARAMETER (LIM8=200)
C LIM11: SIZE OF BUFFER 11
      PARAMETER (LIM11=25)
C LIM13: SIZE OF BUFFER 13
      PARAMETER (LIM13=1)
C LIM15: SIZE OF BUFFER 15
      PARAMETER (LIM15=1)
C LIM16: SIZE OF BUFFER 16
      PARAMETER (LIM16=400)
Thanks very much
Paul
--


Paul R

Paul R. Hutson, Pharm.D.

Associate Professor

UW School of Pharmacy

777 Highland Avenue

Madison WI 53705-2222

Tel  608.263.2496

Fax 608.265.5421

Pager 608.265.7000, p7856

Received on Thu Aug 13 2009 - 13:07:28 EDT

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