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Re: Asterisks in simulated data after changes to maximum observation records and BUFFER

From: Paul Hutson <prhutson>
Date: Fri, 14 Aug 2009 14:44:22 -0500
Many thanks to Dick Brundage for checking my code and data file.  It appears that my NONMEM installation became corrupted when I re-compiled it after modifying the NObs and Buffers.  I thought this not to be the case because the installation ran the CONTROL3 theophylline case without problems.  Thanks to Dennis Fisher as well for his suggestion that the asterisks are from extremely small values.  I still don't know if that was the case, or if there was some other issue that caused it.  He also points out that EXCEL can handle my 68,000 lines of simulated data - I should have been more specific that it was the charting function limit, for which there are of course other options.
Paul

Paul Hutson wrote:
I am attempting to generate 100 iterations of a concentration curve for multiple doses in a single individual.
In order to reflect the input of the extended release dosage form from the dissolution data, I have multiple infusions into the gut representing the amount released in each of these units of time based on the dissolution data.  For 14 doses, then, I am reproducing this, and the data file is quite long (687 records).  I have therefore had to increase NSIZES with respect to the number of observations, as well as increasing buffers 1,2, and 6.

I will need to import the results into R, since excel can't take 687X100 lines of output.  However, regardless of whether I look at my .txt output, or importing it as far as I can into Excel, the output includes asterisks
ID  TIME CMPT IPRE DV PRED RES WRES
  1.0000E+00  0.0000E+00  1.0000E+00  0.0000E+00  0.0000E+00  0.0000E+00  0.0000E+00  0.0000E+00
  1.0000E+00  2.5000E-01  2.0000E+00  1.1193E-05 -5.6330E-02  3.0897E-05 -5.6361E-02  0.0000E+00
  1.0000E+00  2.5000E-01  3.0000E+00  3.6747E-09  3.6747E-09  1.0143E-08 -6.4683E-09  0.0000E+00
  1.0000E+00  2.5000E-01  1.0000E+00  1.1193E-05  0.0000E+00  3.0897E-05  0.0000E+00  0.0000E+00
  1.0000E+00  5.0000E-01  2.0000E+00 *********** *********** *********** ***********  0.0000E+00
  1.0000E+00  5.0000E-01  3.0000E+00 *********** *********** *********** ***********  0.0000E+00

Can anyone explain why I am getting the asterisks in the output (even with only one simulation?  Everything was fine before I  messed with the buffers  (relevant part of SIZES below):
C NO: MAX NO. OF OBSERVATION RECORDS / INDIVIDUAL RECORD
C IF NO IS CHANGED, ALSO RECOMPILE NM-TRAN, NM-TRAN LIBRARY
      PARAMETER (NO=750)
...
C LIM1: SIZE OF BUFFER 1
      PARAMETER (LIM1=800)
C LIM2: SIZE OF BUFFER 2
      PARAMETER (LIM2=800)
C LIM3: SIZE OF BUFFER 3
      PARAMETER (LIM3=200)
C LIM4: SIZE OF BUFFER 4
      PARAMETER (LIM4=50)
C LIM5: SIZE OF BUFFER 5
      PARAMETER (LIM5=200)
C LIM6: SIZE OF BUFFER 6
      PARAMETER (LIM6=800)
C LIM7: SIZE OF BUFFER 7
      PARAMETER (LIM7=2)
C LIM8: SIZE OF BUFFER 8
      PARAMETER (LIM8=200)
C LIM11: SIZE OF BUFFER 11
      PARAMETER (LIM11=25)
C LIM13: SIZE OF BUFFER 13
      PARAMETER (LIM13=1)
C LIM15: SIZE OF BUFFER 15
      PARAMETER (LIM15=1)
C LIM16: SIZE OF BUFFER 16
      PARAMETER (LIM16=400)
Thanks very much
Paul
--


Paul R

Paul R. Hutson, Pharm.D.

Associate Professor

UW School of Pharmacy

777 Highland Avenue

Madison WI 53705-2222

Tel  608.263.2496

Fax 608.265.5421

Pager 608.265.7000, p7856


--
Paul R

Paul R. Hutson, Pharm.D.

Associate Professor

UW School of Pharmacy

777 Highland Avenue

Madison WI 53705-2222

Tel  608.263.2496

Fax 608.265.5421

Pager 608.265.7000, p7856

Received on Fri Aug 14 2009 - 15:44:22 EDT

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