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RE: request for assistance

From: Elassaiss - Schaap, J. <jeroen.elassaiss>
Date: Tue, 1 Dec 2009 23:08:14 +0100

Mark,
 
I have seen this one often enough, but I never tend to save those
results like they are the ones I am proud of ;-).
I would look into initial values, some bugs in the control stream or
model overparameterization.
 
Anyway, a search in a directory tree ended up with one example that
provided this statement in just 1 second. A problem is that the dataset
is proprietary. So here goes a description:
 
-the parent run crashed with a rounding error (1.0 sigdigs)
-I tried 4 variations on the parent model:
1) simplified the $error structure. Crashed with a floating point
2) increased tol to 7 (now I wonder why I did not start with tol=7 in
the first place). Crashed with rounding (0.3 sigdigs) but at a higher
ofv
3) switch to advan9 and decrease in tol: crashed with lsodi1 (ERROR IN
LSODI1: CODE 205) of ID12
4) switch to advan8 and decrease in tol: crashed with the one you
mentioned, for ID7. See below
-I thereafter fixed the error component I removed in 1) which resulted
in a lower ofv.
- Further down the line, I ended up in estimation of this parameter
again.
 
Hope this helps,
Jeroen
 
crash message:
 MONITORING OF SEARCH:
 
0PRED EXIT CODE = 1

0INDIVIDUAL NO. 7 ID=0.70000000E+01 (WITHIN-INDIVIDUAL) DATA
REC NO. 5
 THETA=

 -5.70E+00 -3.60E+00 -3.60E+00 -3.70E+00 0.00E+00 2.40E-01
4.60E+00 7.60E+00 -4.90E+00 -5.20E+00
  4.10E+00 3.00E+00 8.00E-01 -2.00E-01 1.00E+00 3.60E-01
2.50E-01

 OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA

 NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.

 NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR

 TO DIFFERENTIAL EQUATIONS, 5, MAY BE TOO LARGE.

0PROGRAM TERMINATED BY OBJ
 MESSAGE ISSUED FROM ESTIMATION STEP
 AT INITIAL OBJ. FUNCTION EVALUATION
1THERE ARE ERROR MESSAGES IN FILE PRDERR


Jeroen Elassaiss-Schaap, PhD
Modeling & Simulation Expert
Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
Early Clinical Research and Experimental Medicine
Schering-Plough Research Institute
T: +31 41266 9320


  _____

From: owner-nmusers
On Behalf Of Mark Sale - Next Level Solutions
Sent: Tuesday, 01 December, 2009 20:54
To: nmusers
Subject: [NMusers] request for assistance


          Dear collegues,
    Can anyone out there provide me with a data set/control stream that
generates the error:

0PRED EXIT CODE = 1
0INDIVIDUAL NO. 1 ID= 1.00000000000000E+00 =
(WITHIN-INDIVIDUAL)
DATA REC NO. 4
 THETA=
  1.14E+00 -5.36E+00 -1.42E+01 -4.18E+00 9.00E+00 4.21E-01
-6.76E-01 5.63E-01
 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
 NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.

 NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR

 TO DIFFERENTIAL EQUATIONS, 7, MAY BE TOO LARGE

Here is the hard part, it generates after very little run time - ideally
in 10 minutes or less. I have any number that throw this at 4 or 6 (or
24) hours, but that makes debugging it hard.
thanks


Mark Sale MD
Next Level Solutions, LLC
www.NextLevelSolns.com
919-846-9185


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Received on Tue Dec 01 2009 - 17:08:14 EST

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