NONMEM Users Network Archive

Hosted by Cognigen

Standard errors using SAEM

From: Michael.J.Fossler
Date: Wed, 2 Dec 2009 09:56:53 -0500

Hi everyone;

I am currently performing an analysis where I am starting with iterative
two-stage, then SAEM, and finishing off with importance sampling. Here is
the relevant code:

$ESTIMATION METH=ITS INTERACTION NSIG=3 SIGL=6 CTYPE=3 NOABORT
  NITER=100 FILE=RUN19.TTS PRINT=15
$ESTIMATION METH=SAEM INTERACTION NOABORT CTYPE=3 NBURN=300
  NITER=800 FILE=RUN19.SAE PRINT=15
$ESTIMATION METH=IMP INTERACTION ISAMPLE=1000 NITER=10 EONLY=1
FILE=RUN19.IMP
$COVARIANCE
$TABLE ID TIME AGE WT SEX CLR CL V2R V2 V3R V3 EWRES CWRES NPDE
  CPRED PREDI CPREDI MDV ETA1 ETA2 ETA3 ETA6
  FILE=RUN19.CSV FORMAT=,1PE7.4 ONEHEAD NOPRINT

I notice that I am not getting standard errors for any of these runs,
except after the iterative two-stage portion of the analysis, which are
not especially useful. Can anyone shed some light as to what I am leaving
out of my code? I have been through the documentation and can not find
what I am doing wrong, although it is possible (likely!) that I am missing
something.

Thanks,

Mike Fossler
GSK
Received on Wed Dec 02 2009 - 09:56:53 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.