NONMEM Users Network Archive

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RE: Standard errors using SAEM

From: Bauer, Robert <Robert.Bauer>
Date: Wed, 2 Dec 2009 11:46:49 -0500

Try
 
$COVARIANCE UNCONDITIONAL
 
This will give you a standard error from the METHOD=IMP EONLY=1 step
even if there is some positive indefiniteness. But, be cautious about
its quality when such a message occurs.
 


Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions

Tel: (215) 616-6428
Mob: (925) 286-0769
Email: Robert.Bauer
Web: www.icondevsolutions.com

 

 

 


________________________________

From: owner-nmusers
On Behalf Of Michael.J.Fossler
Sent: Wednesday, December 02, 2009 9:57 AM
To: nmusers
Subject: [NMusers] Standard errors using SAEM




Hi everyone;

I am currently performing an analysis where I am starting with iterative
two-stage, then SAEM, and finishing off with importance sampling. Here
is the relevant code:

$ESTIMATION METH=ITS INTERACTION NSIG=3 SIGL=6 CTYPE=3 NOABORT
  NITER=100 FILE=RUN19.TTS PRINT=15
$ESTIMATION METH=SAEM INTERACTION NOABORT CTYPE=3 NBURN=300
  NITER=800 FILE=RUN19.SAE PRINT=15
$ESTIMATION METH=IMP INTERACTION ISAMPLE=1000 NITER=10 EONLY=1
FILE=RUN19.IMP
$COVARIANCE
$TABLE ID TIME AGE WT SEX CLR CL V2R V2 V3R V3 EWRES CWRES NPDE
  CPRED PREDI CPREDI MDV ETA1 ETA2 ETA3 ETA6
  FILE=RUN19.CSV FORMAT=,1PE7.4 ONEHEAD NOPRINT

I notice that I am not getting standard errors for any of these runs,
except after the iterative two-stage portion of the analysis, which are
not especially useful. Can anyone shed some light as to what I am
leaving out of my code? I have been through the documentation and can
not find what I am doing wrong, although it is possible (likely!) that I
am missing something.

Thanks,

Mike Fossler
GSK

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Received on Wed Dec 02 2009 - 11:46:49 EST

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