NONMEM Users Network Archive

Hosted by Cognigen

Assigning occasions to grouped data

From: Seng Kok Yong <skokyong>
Date: Thu, 10 Dec 2009 10:03:35 +0800

Dear all,

 

I would like to obtain some feedback from the group about how to assign
occasions for the estimation of interoccasion variability (IOV). I have
three oral PK datasets:

 

1. concentration-time profiles after multiple doses (first dose at
0h; dosing interval of 24h) from 0 to 96h (56 subjects);
2. concentration-time profiles after multiple doses (first dose at
0h; dosing intervals of 6, 8 or 12h) from 0 to 72h (44 subjects); and
3. concentration-time profiles after a single dose (at 0h) from 0
to 24h (20 subjects).

 

What I would like to do is to combine these three datasets and perform a
popPK analysis. For this purpose, should I define an occasion based on:

 

a. time (e.g. occasion1 for any samples taken during 0 to 24h;
occasion2 for any samples taken during 24 to 48h; ...);
b. ingested dose (e.g. occasion1 includes PK profiles from 0 to 24h
for dataset #1, PK profiles from 0 to 6h, 0 to 8h or 0 to 12h for
dataset #2, and PK profiles from 0 to 24h for dataset #3; occasion2
denotes PK profiles from 24 to 48h for dataset #1, and PK profiles from
6 to 12h, 8 to 16h or 12 to 24h for dataset #2; ...); or
c. others?

 

Based on preliminary analysis of dataset #3, the average elimination
half-life is 3h.

 

Thank you in advance for your kind advice.

 

Best wishes,

Kok-Yong Seng

 

DSO National Laboratories

Republic of Singapore

 


Received on Wed Dec 09 2009 - 21:03:35 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.