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11th Fisher/Shafer NONMEM/PLT Tools Workshop

From: Steven Shafer <steven.shafer>
Date: Thu, 10 Dec 2009 11:28:43 -0800

Dear Colleagues:


Dennis Fisher and I are delighted to announce our 11th NONMEM /PLT Tools
Workshop, which will be held in San Francisco from April 13th through April
17th, 2010. You can find the course description and registration details at
<> San Francisco is our
most popular course, so early booking is recommended.


This is an intermediate to advanced course on the use of the NONMEM system,
closely integrated with the PLT Tools graphical user interface for the
NONMEM System. Although the focus of the workshop is NONMEM, the more
advanced diagnostics (e.g., visual predictive check, log-likelihood
profiling, bootstrap analysis, and jackknife validation) are presented in
the context of PLT Tools because it automates the generation of these


Dennis and I are particularly pleased to use this workshop to introduce a
new feature of PLT Tools: automatic covariate identification. A set of
routines built into PLT Tools permit automated exploration of the
relationship between covariates and model parameters by creating NONMEM
control files that systematically evaluate the matrix of model parameters
and patient covariates.


The workshop will be based on NONMEM VI. With the imminent release of NONMEM
7 by Globomax, Dennis and I have worked hard to see that PLT Tools is
compatible with NONMEM 7. If you are using NONMEM 7, or intend to switch to
NONMEM 7, the version of PLT Tools that we will distribute with the workshop
should ease the transition.


Our NONMEM Workshops is now in their 6th year. Dennis and I have spent the
past three years developing PLT Tools. We introduced PLT Tools as the
workshop platform for the 9th Fisher/Shafer NONMEM course in Bethesda,
Maryland, giving participants in that course access to bootstrap analysis,
log-likelihood profiling, and jackknife analysis, in addition to the
outstanding diagnostic graphics from PLT Tools. The latest version
incorporates suggestions from the attendees at the last NONMEM workshop in
Basel, Switzerland, including time after dose graphics, improved bootstrap
handling, and full compatibility with NONMEM 7 and NMQUAL.


You can download the completely functional unlicensed version of PLT Tools
from <> Model validation is
facilitated with automated procedures for visual predictive checks, log
likelihood profiling, jack-knife analysis, and extensive bootstrap analysis
for determination of standard errors. PLT Tools also includes a robust
library of control streams and a control stream editor. CFR 11 Part 22
compliance is built into the program, as is extensive run archiving and
creation of audit trails. PLT Tools also includes a comprehensive set of
graphical and statistical analyses facilitate model development and testing.
A sample output can be downloaded from <>


The licensed version of PLT Tools supports multiple simultaneous NONMEM
runs, which can substantially facilitate throughput on multicore computers.
A multiuser networked version of PLT Tools is also available. The multiuser
networked version can distribute NONMEM jobs across multiple networked


One of the joys of teaching this course is the considerable evolution in
course material every time the workshop is offered. Dennis and I continuous
update the course materials, based both on feedback from course participants
and our own exploration of novel pharmacometric problems. The feedback from
the 9th and 10th courses indicated that PLT Tools was exceedingly well
received, and workshop participants appreciated their having access to these
advanced and powerful tools.


Dennis and I hope to see you in April in San Francisco!




Steven L. Shafer, MD

Professor of Anesthesiology, Columbia University

Adjunct Professor of Anesthesia, Stanford University

Adjunct Professor of Biopharmaceutical Sciences, UCSF

Editor-in-Chief, Anesthesia & Analgesia


Received on Thu Dec 10 2009 - 14:28:43 EST

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