NONMEM Users Network Archive

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Release PsN version 3.1.0

From: Sebastian Ueckert <sebastian.ueckert>
Date: Mon, 14 Dec 2009 16:13:17 +0100

Dear PsN users,

PsN 3.1.0 is now available for download from http://psn.sourceforge.net

The most important changes since 3.0.0 are a completely rewritten parser
for THETA/OMEGA/SIGMA and significantly extended NONMEM7 support.

Best regards,
Sebastian Ueckert


******************************
*******
Changes from PsN 3.0.0 to 3.1.0

***New documentation***

- The document PsN_and_NONMEM7.pdf describes how PsN deals with the many
new features and functions of NONMEM7. This document is essential for
anyone who intends to use PsN with NONMEM7.

***New features 3.1.0***

- Extensive NONMEM7 support. All PsN tools accept modelfiles with
multiple $ESTIMATION. All estimation methods are supported. Please note:
only results from last $EST will be presented and used in data processing.

- New parser for THETA, OMEGA and SIGMA. With the new parser all known
bugs are removed. All formatting variants described in the NONMEM
userguide are supported.

- tweak_inits will ensure that OMEGA and SIGMA are strictly diagonally
dominant. This reduces the risk of NONMEM halting due to non-postive
definite initial estimate matrices. Also, tweak_inits will not change
initial estimates that are zero, regardless if they are FIXED or not.
This preserves band matrices.

- New options -predcorr (prediction correction) and -varcorr
(variability correction, experimental) to vpc. More details in the vpc
userguide.

- New options -last_est_complete and -niter_eonly for tools that run
some models with skipped estimation step (cdd, npc, vpc, execute with
mirror_plots option). More details in PsN_and_NONMEM7.pdf.

- update_inits now has options for renumbering output files in $TABLE
and adding comments in $PROBLEM

- Both run information files version_and_option_info.txt and command.txt
will be overwritten at each rerun in the same PsN directory, also for
npc and vpc. The files from the original PsN call are saved as
original_command.txt and original_version_and_option_info.txt

- The logic for the flag minimization_successful has been adapted to new
the estimation methods. Affects retries and sumo output. More details in
PsN_and_NONMEM7.pdf

- For developers only: Many accessors to the output object have changed.
 Contact the PsN development team for more information.




Sebastian Ueckert, MSc, PhD student
-----------------------------------------------
Pharmacometrics Research Group,
Department of Pharmaceutical Biosciences,
Uppsala University
-----------------------------------------------
P.O. Box 591
SE-751 24 Uppsala
Sweden
-----------------------------------------------
sebastian.ueckert
-----------------------------------------------
Work: +46-(0)18-471 4291

Received on Mon Dec 14 2009 - 10:13:17 EST

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