NONMEM Users Network Archive

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Re: simulation question

From: Sebastian Ueckert <sebastian.ueckert>
Date: Fri, 6 Feb 2009 10:51:19 +0100

Dear Ethan,
the simplest solution to solve your problem would be to use the bootstrap
command of PSN ( With PSN installed you would
simply do:

bootstrap final_model.mod -samples=200

PSN would take care of unsuccessful runs and provide a nice summary of the
individual estimates.

Best regards

On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <ethan.wu75

> Dear users,
> I am trying to compare several specific PK/PD study designs by:
> -- run 200 simulations with the final model (develope from original
> dataset)
> -- fit the final model to the 200 simulated dataset
> To achieve above, I used $SIM SUBPROB=200 option
> however, nonmem would completely stop after running
> into estimation problem at one specific simulation/estimation cycles, for
> some designs it stop even before 10th iterations.
> Is there anyway nonmem could continue go on?
> Or, does someone know alternative way to achieve the goal?
> thanks

Received on Fri Feb 06 2009 - 04:51:19 EST

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