NONMEM Users Network Archive

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RE: simulation question

From: Martin Bergstrand <martin.bergstrand>
Date: Fri, 6 Feb 2009 11:52:09 +0100

Dear all,

 

PsN is useful tool for this purpose but I think that the functionality that
should be used is called "Stochastic Simulation and Estimation (SSE)". The
Bootstrap functionality is primarily used for obtaining parameter
uncertainties. A detailed userguide for the SSE functionality is presented
at the PsN webpage (see link below).

 

http://psn.sourceforge.net/PDF_docs/sse_userguide.pdf

 

Write to the PsN mailing list if you experience any troubles and need help
(psn-general

 

Best regards,

Martin

 

From: owner-nmusers
Behalf Of Sebastian Ueckert
Sent: Friday, February 06, 2009 10:51
To: Ethan Wu
Cc: nmusers
Subject: Re: [NMusers] simulation question

 

Dear Ethan,
the simplest solution to solve your problem would be to use the bootstrap
command of PSN (http://psn.sourceforge.net/). With PSN installed you would
simply do:

bootstrap final_model.mod -samples=200

PSN would take care of unsuccessful runs and provide a nice summary of the
individual estimates.

Best regards
Sebastian

On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <ethan.wu75

Dear users,

  I am trying to compare several specific PK/PD study designs by:

 -- run 200 simulations with the final model (develope from original
dataset)

 -- fit the final model to the 200 simulated dataset

To achieve above, I used $SIM SUBPROB=200 option

 however, nonmem would completely stop after running into estimation
problem at one specific simulation/estimation cycles, for some designs it
stop even before 10th iterations.

Is there anyway nonmem could continue go on?

Or, does someone know alternative way to achieve the goal?

thanks

 

 

 



Received on Fri Feb 06 2009 - 05:52:09 EST

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