NONMEM Users Network Archive

Hosted by Cognigen

Re: simulation question

From: Gastonguay, Marc <marcg>
Date: Fri, 6 Feb 2009 06:13:09 -0500

Ethan,
As Leonid suggests, you may want to control NONMEM runs using an
external tool and an INFN routine for extraction of results. MIfuns,
an open-source R package, provides functions for this sort of
automation. Template INFN codes are provided as well. It's a free
download:
http://metruminstitute.org/downloads/index.shtml

R is good choice for this purpose because you can also script tasks
such as data preparation, post processing of output and graphics and
table creation - all within the same language. Other options for this
sort of automation use a variety of scripting languages. Some examples
are: Perl-Speaks NONMEM (PSN), Wings for NONMEM (WFN) and others...
see the PAGE website for links to these projects (http://www.page-meeting.org/
).

Good luck,
Marc

Marc R. Gastonguay, Ph.D.
President & CEO, Metrum Research Group LLC [www.metrumrg.com]
Scientific Director, Metrum Institute [www.metruminstitute.org]
Direct: 860-670-0744 Main: 860-735-7043
Email: marcg




On Feb 5, 2009, at 5:18 PM, Ethan Wu wrote:

> Dear users,
> I am trying to compare several specific PK/PD study designs by:
> -- run 200 simulations with the final model (develope from original
> dataset)
> -- fit the final model to the 200 simulated dataset
> To achieve above, I used $SIM SUBPROB=200 option
> however, nonmem would completely stop after running into
> estimation problem at one specific simulation/estimation cycles, for
> some designs it stop even before 10th iterations.
> Is there anyway nonmem could continue go on?
> Or, does someone know alternative way to achieve the goal?
> thanks
>
>
>


Received on Fri Feb 06 2009 - 06:13:09 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.