NONMEM Users Network Archive

Hosted by Cognigen

RE: Population predictions vs individual predictions

From: Serge Guzy <GUZY>
Date: Fri, 6 Feb 2009 09:46:30 -0800

When you perform a population analysis, the program returns the
population means as well as the individual parameter estimates (mode of
the individual conditional distributions). If you plug the population
means values into your model and for each patient, you will get back the
population predicted values for each patient. If all patients had the
same dosing conditions as well as the same observation times, then the
population predicted profiles would be the same for each patient.
If you plug now the individual parameter estimated into your model and
for each patient, you will get the individual predictions for each
Serge Guzy
President, CEO; POP-PHARM; Inc.

-----Original Message-----
From: owner-nmusers
On Behalf Of Hudachek,Susan
Sent: Friday, February 06, 2009 7:16 AM
To: nmusers
Subject: [NMusers] Population predictions vs individual predictions

Greetings! I am looking for a clarification/explaination of the
difference between population-predicted values (say for concentration)
and individual-predicted values. Thank you to anyone who can provide

Susan Hudachek, M.S., Ph.D.
Animal Cancer Center
Veterinary Teaching Hospital
Colorado State University
300 West Drake Road
Fort Collins, CO 80523-1620
PHONE: (970) 219-7599
FAX: (970) 297-1254
EMAIL: Susan.Hudachek

The information contained in this email message may
contain confidential or legally privileged information and is intended sole=
for the use of the named recipient(s). No confidentiality or privilege is=
waived or lost by any transmission error. If the reader of this message is=
not the intended recipient, please immediately delete the e-mail and all
copies of it from your system, destroy any hard copies of it and notify the=
sender either by telephone or return e-mail. Any direct or indirect use,=
disclosure, distribution, printing, or copying of any part of this message =
prohibited. Any views expressed in this message are those of the individua=
sender, except where the message states otherwise and the sender is
authorized to state them to be the views of XOMA.
Received on Fri Feb 06 2009 - 12:46:30 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: