NONMEM Users Network Archive

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RE: Population predictions vs individual predictions

From: Serge Guzy <GUZY>
Date: Fri, 6 Feb 2009 09:46:30 -0800

When you perform a population analysis, the program returns the
population means as well as the individual parameter estimates (mode of
the individual conditional distributions). If you plug the population
means values into your model and for each patient, you will get back the
population predicted values for each patient. If all patients had the
same dosing conditions as well as the same observation times, then the
population predicted profiles would be the same for each patient.
If you plug now the individual parameter estimated into your model and
for each patient, you will get the individual predictions for each
patient.
Best
Serge Guzy
President, CEO; POP-PHARM; Inc.

-----Original Message-----
From: owner-nmusers
On Behalf Of Hudachek,Susan
Sent: Friday, February 06, 2009 7:16 AM
To: nmusers
Subject: [NMusers] Population predictions vs individual predictions

Greetings! I am looking for a clarification/explaination of the
difference between population-predicted values (say for concentration)
and individual-predicted values. Thank you to anyone who can provide
this!

Susan Hudachek, M.S., Ph.D.
Animal Cancer Center
Veterinary Teaching Hospital
Colorado State University
300 West Drake Road
Fort Collins, CO 80523-1620
PHONE: (970) 219-7599
FAX: (970) 297-1254
EMAIL: Susan.Hudachek

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Received on Fri Feb 06 2009 - 12:46:30 EST

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