NONMEM Users Network Archive

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RE: simulation question

From: Serge Guzy <GUZY>
Date: Fri, 6 Feb 2009 09:51:18 -0800

Do you bootstrap the individual patients X times and then fit the model
to these new datasets or do you simulate datasets based on the final
population characteristics you already established? Both options are
also automated in the PDX-MC-PEM program and I think also in SADAPT.





From: owner-nmusers
On Behalf Of Sebastian Ueckert
Sent: Friday, February 06, 2009 1:51 AM
To: Ethan Wu
Cc: nmusers
Subject: Re: [NMusers] simulation question


Dear Ethan,
the simplest solution to solve your problem would be to use the
bootstrap command of PSN ( With PSN
installed you would simply do:

bootstrap final_model.mod -samples=200

PSN would take care of unsuccessful runs and provide a nice summary of
the individual estimates.

Best regards

On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <ethan.wu75

Dear users,

  I am trying to compare several specific PK/PD study designs by:

 -- run 200 simulations with the final model (develope from original

 -- fit the final model to the 200 simulated dataset

To achieve above, I used $SIM SUBPROB=200 option

 however, nonmem would completely stop after running into estimation
problem at one specific simulation/estimation cycles, for some designs
it stop even before 10th iterations.

Is there anyway nonmem could continue go on?

Or, does someone know alternative way to achieve the goal?





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Received on Fri Feb 06 2009 - 12:51:18 EST

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