NONMEM Users Network Archive

Hosted by Cognigen

Metrum Institute 2009 Course Offerings

From: Gastonguay, Marc <marcg>
Date: Sun, 8 Feb 2009 21:01:00 -0500

Metrum Institute is pleased to announce several training course
offerings for 2009!

We've added two new courses this year: MI101: Introduction to
Pharmacokinetics and Pharmacodynamics, and MI220: R Programming for
Pharmacometrics. In addition, our popular introductory Bayesian
modeling course (MI250) has been revised to include new material
focused on the use of the new BUGS PK-PD model library.

Please see www.metruminstitute.org/training for more details and for
registration information. Academic/non-profit discounts are available. =

As always, Metrum Institute training course revenues support our non-
profit research, development and service activities. - Thank you for
your support.

Graduate students / graduate advisors seeking to establish academic
credit for Metrum Institute courses may contact me directly: =
marcg
.

Thank you.

Marc

Marc R. Gastonguay, Ph.D. [ marcg
Scientific Director and Chairman
Metrum Institute [ www.metruminstitute.org ]

(apologies for duplicate postings)



---- Metrum Institute 2009 Training Courses ----



MI101: Introduction to Pharmacokinetics and Pharmacodynamics

3 Cr • Sep 14–Dec 23 2009 (12 weeks plus 1 make-up week) • Mon 7–9=
 pm,
Wed 7–8 pm (1) • Live Webcast • MI101 provides a thorough =
introduction
to fundamental concepts in pharmacokinetics and pharmacodynamics
through lectures and problem-solving lab sessions emphasizing
physiologic concepts and real-world applications. Content in this
course is consistent with expectations for an introductory
pharmacokinetics course in a professional Pharmacy curriculum.



MI110: NMQUAL for NONMEM® Software Installation and Qualification

No Cr • Multiple offerings: March 11, June 25, Sep 14, and Dec 9 2009 =

(1 session each) • 1–3 pm (1) • Live Webcast • MI110 =
demonstrates
basic NMQual techniques on a Windows platform, with the aim of
executing rapid, well characterized NONMEM® installations.


MI120: Brief Introduction to R and MIfuns

No Cr • Multiple Offerings: March 24 and 27; Sep 15 and 18 2009 (2 =

days each) • Tue 2–4 pm, Fri 2–4 pm • Live Webcast • MI120 =
is a
brief but intensive hands-on introduction to the R language, with
specific focus on functions and features useful in pharmacometrics.
This course also includes an introduction to the MIfuns package, which =

is used in later courses for processing of NONMEM® runs and other
modeling/simulation tasks. Students will be given access to a Metrum
Institute web-application server for hands-on examples.


MI210: Essentials of Population PK-PD Modeling and Simulation

3 Cr • Sep–Dec 2010, exact dates TBD (12 weeks plus 2 make-up weeks) =

Tue 2–4 pm, Fri 2–3 pm (1) • Live Webcast • MI210 provides an =

extensive overview of topics in population pharmacokinetics and
pharmacodynamics, including nonlinear-mixed effects modeling theory
and implementation, data formatting requirements, population model
development, model evaluation techniques, continuous PK-PD models,
Monte Carlo simulation, and best practices. Instruction combines
didactic lectures with hands-on exercises using R, MIfuns, and the
NONMEM® software. Students will be given access to a Metrum Institute =

web-application server for hands-on examples.


MI212: Advanced Topics in Population PK-PD Modeling and Simulation

3 Cr • Sep 8–Dec 17 2009, (12 weeks plus 1 make-up week) • Tue 2–4=
 pm,
Fri 2–3 pm (1) • Live Webcast • MI212 builds upon the material =
covered
in MI210. It provides a detailed overview of advanced topics in
population pharmacokinetics and pharmacodynamics: inter-occasion
variability, mixture models, truncated continuous data (BQL),
nonlinear-pharmacokinetic models, models for parent and metabolite
plasma and urine data, indirect-response pharmacodynamic models,
models for tolerance, precursor pools, cell lifespan, and other semi-
mechanistic systems, disease progression models, population PK study
design, and clinical trial simulation. Instruction combines didactic
lectures with hands-on exercises using R, MIfuns, and the NONMEM®
software. Students will be given access to a Metrum Institute web-
application server for hands-on examples.

MI220: R Programming for Pharmacometrics

2 Cr • Feb 18–May 29 2009 (12 weeks plus 2 make-up weeks) • Wed =
and
Fri 12–1 pm (1) • Live Webcast • MI220 covers introductory through =
 
intermediate-level R programming topics with a focus on pharmacometric =

applications through lectures and hands-on lab sessions. Topics
include basic R language constructs, data import/export, writing
scripts and functions, manipulating data objects, traditional and
lattice graphics, and basic statistical methods. This course also
makes extensive use of the MIfuns package to teach and implement tasks =

such as population PK data set assembly, post-processing of Maximum
Likelihood and Bayesian modeling output, exploratory and report-
quality graphics and tables, and automation of compute intensive
methods, such as bootstrapping and posterior predictive check model
qualification. Students will be given access to a Metrum Institute web- =

application server for hands-on examples.



MI250: Introduction to Bayesian Modeling and Simulation and the BUGS
PK-PD Model Library

3 Cr • June 3–5, 2009 • Wed–Fri 8:30 am–4:30 pm (1) • =
Location: Metrum
Institute, Tariffville, CT • MI250 is an intensive, hands-on, 3-day =

course that provides an introduction to Bayesian modeling theory and
the practical use of WinBUGS and R for PK-PD applications. In addition =

to basic concepts, this new course includes instruction on the BUGS PK- =

PD model library, an open-source tool developed by Metrum Institute.
This library facilitates the implementation of population PK-PD models =

in WinBUGS for compartmental models described by algebraic, general
linear and differential equations. Hands-on software requirements
include WinBUGS and R (both freely available). Students will provide
their own laptop computers.


MI255: Exposure-Response Modeling of Categorical, Count and Time-to-
Event Data Using Bayesian and Maximum Likelihood Methods

3 Cr • July 13-15, 2009 • Mon–Wed 8:30 am–4:30 pm (1) • =
Location:
Metrum Institute, Tariffville, CT • MI255 is an intensive, hands-on, =
3-
day course providing an introduction to modeling of categorical,
count, and time-to-event data, and the practical use of WinBUGS and
NONMEM® for such applications. The course provides some basic theory =

and illustrates some of the advantages of using Bayesian methods for
these types of data sets. Hands-on software requirements include
WinBUGS and R (both freely available). Students will provide their own =

laptop computers.



(1) All Times Eastern, US

For more information and to register, please see: =
http://www.metruminstitute.org/training

©Metrum Institute 2008, 2009 • NONMEM® is licensed and distributed =
by
ICON Development Solutions.



Received on Sun Feb 08 2009 - 21:01:00 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.