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PD of drugs in combination therapy

From: Fatemeh Akhlaghi, PhD <fak4939u>
Date: Mon, 26 Jan 2009 21:50:20 -0500


I was wondering if anyone has experience modeling the effect of three separate
drugs on the same biomarker. In my area of research in organ transplantation,
patients often take three immunosuppressive agents concomitantly, all of which
will contribute toward a PD marker (i.e. reduction of intracellularly
expressed IL-2 in mitogen stimulated lymphocytes). Most published work on
drug combinations, however, deal with agonistic or antagonistic activity of
two drugs as summarized by Jonker et al, 2005.

All suggestions or advice are greatly appreciated.


Fatemeh Akhlaghi, PharmD, PhD
Associate Professor in Pharmacokinetics
Biomedical and Pharmaceutical Sciences (BPS)
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881, USA

Phone/Fax: (401) 874 9205/(401) 874 2181
Email: fatemeh
Laboratory Website:
Received on Mon Jan 26 2009 - 21:50:20 EST

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