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RE: PD of drugs in combination therapy

From: Mouksassi Mohamad-Samer <mohamad-samer.mouksassi>
Date: Tue, 27 Jan 2009 18:00:25 -0500

Dear Fatemeh,

Some work regarding three drug combinations has been published regarding =
anesthetic combinations:

Flexible interaction model for complex interactions of multiple =
Fidler M, Kern SE.
Anesthesiology. 2006 Aug;105(2):286-96.

Response surface model for anesthetic drug interactions.
Minto CF, Schnider TW, Short TG, Gregg KM, Gentilini A, Shafer SL.
Anesthesiology. 2000 Jun;92(6):1603-16.

These models can handle up to three drugs ( appendix of the before =
mentioned manuscripts).

Hope this helps,


-----Original Message-----
From: owner-nmusers
Sent: Mon 1/26/2009 21:50
To: nmusers
Subject: [NMusers] PD of drugs in combination therapy

I was wondering if anyone has experience modeling the effect of three =
drugs on the same biomarker. In my area of research in organ =
patients often take three immunosuppressive agents concomitantly, all of =
will contribute toward a PD marker (i.e. reduction of intracellularly
expressed IL-2 in mitogen stimulated lymphocytes). Most published work =
drug combinations, however, deal with agonistic or antagonistic activity =
two drugs as summarized by Jonker et al, 2005.

All suggestions or advice are greatly appreciated.


Fatemeh Akhlaghi, PharmD, PhD
Associate Professor in Pharmacokinetics
Biomedical and Pharmaceutical Sciences (BPS)
University of Rhode Island
125 Fogarty Hall, 41 Lower College Road
Kingston, RI 02881, USA

Phone/Fax: (401) 874 9205/(401) 874 2181
Email: fatemeh
Laboratory Website:

Received on Tue Jan 27 2009 - 18:00:25 EST

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