NONMEM Users Network Archive

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RE: NONMEM 7 Update

From: HKAG <hkag>
Date: Fri, 3 Jul 2009 08:57:58 +0200

Dear all

Just one minor comment from one of the not hard core users of NONMEM.

Only 3 years ago I was afraid that NONMEM would die, since no one really se=
emed to be interested in investing in the software. Today, in my eyes, NONM=
EM has been brought back on the scene by IDS - that is highly appreciated.

I think we all have to realize that NONMEM is not open source software, the=
re are both advantages and dis-advantages connected to that. As long as IDS=
 ensures that we are able to make minor adjustments (like nsizes etc), I do=
n't see a big problem.

Right now I run the R software (+census and xpose), together with NONMEM, a=
nd find thats some of the best pices of open software I have seen. But I do=
nt think the PKPD community is big enough for us to generate comparable sof=
tware for PKPD modelling, and if we need professionel companies to develop =
our software, we will have to accept other terms.

Instead I think we should focus on the positive side, NONMEM is alive, and =
if anyone wants to run an older version of NONMEM that's fine with me. But =
I will test version 7.0 - and I look forward to the release.

Hope everyone will have a nice summer

Br henrik
 _________________________________

Henrik Agersø
Director, Head of Exploratory ADME, BRU
Novo Nordisk A/S
Novo Nordisk Park
DK-2760 Måløv
Denmark
+45 4442 3522 (direct)
+45 3079 3522 (mobile)
hkag
www.novonordisk.com<http://www.novonordisk.com/>

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/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment=
1.asp>

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________________________________
From: owner-nmusers
 Behalf Of Eleveld, DJ
Sent: 02 July 2009 23:32
To: Ludden, Thomas; nmusers
Cc: Krohn, Anthony
Subject: RE: [NMusers] NONMEM 7 Update


Dear all:

There is no debate at all that investment in NONMEM should have a healthy r=
eturn. I just dont understand how encryption is supposed to help.

NONMEM 6 was not encrypted, what problems resulted from this? Did anything=
 actually happen to the NONMEM 6 source code which must be avoided with NON=
MEM 7?

The thinking "we must encrypt our souce code so nobody steals our IP" may b=
e suitable for consumer goods where copyright violations are rampant and vi=
sibility is very low. But the small, highly specalized and very visible co=
mmunity of PK-PD analysis is a very different thing. My impression is that=
 everyone takes thier NONMEM licences very seriously and I dont see any rea=
son why this would change with NONMEM 7.

There are usually upsides and downsides to these kinds of choices and a bal=
ance must be struck. I can think of a number of downsides to encryption bu=
t no real upsides. I was hoping to hear from others what the upside was. =
Just "protecting our IP" is, in my opinion, not a real reason becasue this =
does not actually generate any revenue.

Douglas Eleveld


-----Oorspronkelijk bericht-----
Van: Ludden, Thomas [mailto:Thomas.Ludden
Verzonden: do 2-7-2009 15:15
Aan: Eleveld, DJ; nmusers
CC: Krohn, Anthony
Onderwerp: RE: [NMusers] NONMEM 7 Update

Dear All:

        Icon Development Solutions has invested in the further
development of NONMEM. By mutual agreement with the University of
California at San Francisco, NONMEM 7 is intellectual property belonging
to IDS. However, IDS will continue to pay royalties to UCSF.

        The business plan under which NONMEM 7 was developed calls for
the protection of the I.P. involved. In addition, NONMEM 7 contains
several updated routines developed and owned by IMSL (Visual Numerics
Inc.). Our agreement with IMSL stipulates that we will not distribute
their source code. The installer will compile the software but will not
allow the unencrypted source code to remain on the users computer. The
licensing agreement will also stipulate that any attempt to access the
source code will be a violation of the agreement.

        Some source code will be left unencrypted for various reasons,
one being the need for users to change certain values in SIZES and
perhaps other resource routines.



        Tom

        Thomas M. Ludden Ph.D.
        Vice-President, Pharmacometrics R&D
        ICON Development Solutions

        Tel: + 1 410 696 3040
        Mob: + 1 410 258 2411
        Fax: + 1 410 480 0776
        Email: thomas.ludden

        Web: www.icondevsolutions.com


<http://emailsignature/stationary/Icon_Development_Solutions.gif>






________________________________

From: Eleveld, DJ [mailto:d.j.eleveld
Sent: Thursday, July 02, 2009 6:11 AM
To: Ludden, Thomas; nmusers
Subject: RE: [NMusers] NONMEM 7 Update


Can anyone explain what advantages encryted source code might have?

For me at least, the NONMEM source code is already functionally
encrypted because of my poor understanding of Fortran. But it is
unclear to me what problem encryted source code actually solves. Can
anyone enlighten me?

Douglas Eleveld

________________________________

From: owner-nmusers
Sent: Wed 01/07/2009 9:21 PM
To: nmusers
Subject: [NMusers] NONMEM 7 Update


Dear All:

This is just a brief update regarding the availability of NONMEM 7. We
had hoped to begin distribution of this new version at this time.
However, there are some final code changes to be made followed by
thorough testing. We hope to be able to begin distribution in early
August.

Please be certain that the contact information that we have on file for
your license(s) is up to date. This is the person to whom NONMEM 7 will
be sent . Please send any updates regarding the correct contact person
to IDSSOFTWARE

Please note that NONMEM 7 will have a licensing system. More details
will be provided as we approach the release date.

Our experience with distributing binary code to the beta testers was
very mixed. Some testers had no problems; others had considerable
difficulty with achieving a successful installation. We are now
considering the distribution of NONMEM 7, for the most part, as
encrypted source code. An installation program will be included. The
SIZES file and several other resource files will be left unencrypted so
that the user can make desired changes prior to compilation as was
possible with previous versions. This change in our method of
distribution will require that a revised licensing agreement be
executed.

Regards,

Bob Bauer
Vice-President, Pharmacometrics

Alison Boeckmann
Consultant

Bill Bachman
Director, Pharmacometrics R&D

Tom Ludden
Vice-President, Pharmacometrics R&D

ICON Development Solutions

Tel: + 1 410 696 3040
Mob: + 1 410 258 2411
Fax: + 1 410 480 0776
Email: thomas.ludden

Web: www.icondevsolutions.com



ICON plc made the following annotations.
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Registered number: 145835


________________________________

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that is intended only for the individual or entity named in the e-mail addr=
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are not the intended recipient, you are hereby notified that any disclosure=
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ibited. If
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e.
Thank You,
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South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835



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De inhoud van dit bericht is vertrouwelijk en alleen bestemd voor de geadre=
sseerde(n). Anderen dan de geadresseerde(n) mogen geen gebruik maken van di=
t bericht, het niet openbaar maken of op enige wijze verspreiden of vermeni=
gvuldigen. Het UMCG kan niet aansprakelijk gesteld worden voor een incomple=
te aankomst of vertraging van dit verzonden bericht.

The contents of this message are confidential and only intended for the eye=
s of the addressee(s). Others than the addressee(s) are not allowed to use =
this message, to make it public or to distribute or multiply this message i=
n any way. The UMCG cannot be held responsible for incomplete reception or =
delay of this transferred message.

Received on Fri Jul 03 2009 - 02:57:58 EDT

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