NONMEM Users Network Archive

Hosted by Cognigen

Re: RE: NONMEM 7 Update

From: Alice Nichols <NICHOLA2>
Date: Mon, 06 Jul 2009 08:35:17 -0400

The fact that NONMEM7 will not be open source code is very unfortunate,
it has not been often, but there have been occasions when by going over =
the source code I was able to understand aspects of NONMEM programming =
that were still unclear to me,
being able to get a look at the actual algorithms in software had been a =
major advantage for NONMEM!!!!
Alice I Nichols, PhD
Sr Director
Early Development and Clinical Pharmacology
Wyeth Research
500 Arcola Rd
Collegeville, PA 19426
tel: 484-865-8741/ fax: 484-865-9075

>>> "Serge Guzy" <GUZY

I do have only one simple question. How many people took advantage from =
the fact Nonmem was distributed as open source? If we are talking about a =
very small percentage, is this discussion worthwhile? How many people =
except bob bauer and may be somebody else I am not aware of are able to =
follow and understand the cuirrent nonmem code?
From: owner-nmusers
To: Ludden, Thomas ; nmusers
Sent: Thu Jul 02 23:46:09 2009
Subject: [NMusers] RE: NONMEM 7 Update

 Thomas Didn't ICON consider that indeed, this decision might stimulate =
the divergence of an open-source clade of NONMEM, somewhat like R stemmed =
out of S-plus? If a small academic group starts to work in that direction, =
it would certainly be quickly joined by many* Thierry BuclinUniv. =
Hospital, Lausanne De : owner-nmusers] De la part de Ludden, Thomas
Envoyé : jeudi, 2. juillet 2009 15:15
À : Eleveld, DJ; nmusers
Cc : Krohn, Anthony
Objet : RE: [NMusers] NONMEM 7 Update

 Dear All:Icon Development Solutions has invested in the further developmen=
t of NONMEM. By mutual agreement with the University of California at San =
Francisco, NONMEM 7 is intellectual property belonging to IDS. However, =
IDS will continue to pay royalties to UCSF. The business plan under =
which NONMEM 7 was developed calls for the protection of the I.P. =
involved. In addition, NONMEM 7 contains several updated routines =
developed and owned by IMSL (Visual Numerics Inc.). Our agreement with =
IMSL stipulates that we will not distribute their source code. The =
installer will compile the software but will not allow the unencrypted =
source code to remain on the users computer. The licensing agreement will =
also stipulate that any attempt to access the source code will be a =
violation of the agreement. Some source code will be left unencrypted for =
various reasons, one being the need for users to change certain values in =
SIZES and perhaps other resource routines.Tom
Thomas M. Ludden Ph.D.
Vice-President, Pharmacometrics R&D
ICON Development Solutions Tel: + 1 410 696 3040
Mob: + 1 410 258 2411
Fax: + 1 410 480 0776
Email: thomas.ludden

The information contained in this email message may contain confidential =
or legally privileged information and is intended solely for the use of =
the named recipient(s). No confidentiality or privilege is waived or lost =
by any transmission error. If the reader of this message is not the =
intended recipient, please immediately delete the e-mail and all copies of =
it from your system, destroy any hard copies of it and notify the sender =
either by telephone or return e-mail. Any direct or indirect use, =
disclosure, distribution, printing, or copying of any part of this message =
is prohibited. Any views expressed in this message are those of the =
individual sender, except where the message states otherwise and the =
sender is authorized to state them to be the views of XOMA.

Received on Mon Jul 06 2009 - 08:35:17 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: