NONMEM Users Network Archive

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covariance step

From: Varsha Mehta <varsham>
Date: Thu, 16 Jul 2009 13:21:09 -0400


Dear NONMEM users:

I have a data set for 30 infants where I am running a 2 COMPT PK model. I =
got the following error message for the covariance step. I need some help =
with trying to fix this error. Any suggestions? should I increase the =
upper boundries of initial estimates?



MINIMIZATION SUCCESSFUL
 NO. OF FUNCTION EVALUATIONS USED: 289
 NO. OF SIG. DIGITS IN FINAL EST.: 3.0
0PARAMETER ESTIMATE IS NEAR ITS BOUNDARY
 THIS MUST BE ADDRESSED BEFORE THE COVARIANCE STEP CAN BE IMPLEMENTED

any help is appreciated.
Thanks


Varsha Mehta, MS(CRDSA), Pharm.D., FCCP
Clinical Associate Professor
Pharmacy, Pediatrics and Communicable Diseases
Clinical Pharmacist Neonatal Critical Care
University of Michigan
(O) 734-936-8985
(F) 734-936-6946
varsham

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Received on Thu Jul 16 2009 - 13:21:09 EDT

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