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Exiting position in the Pharmacometrics group at GSK

From: roberto.a.gomeni
Date: Mon, 1 Jun 2009 14:36:51 +0200

Senior Statistical Modeller
Location: Research Triangle Park (RTP), NC USA or Harlow, UK

At GSK, within the newly created Pharmacometrics (PMx) group, have an
opportunity for a senior Statistical Modeller. The candidate will be
responsible for implementing innovative analytical methods to interpret
and describe pharmacology, physiology and disease in a quantitative
fashion by integrating and applying statistical models to characterize,
understand, gain insights into the determinants of efficacy and safety
outcomes, predict a drug?s and biomarker-outcome, optimize drug
development plans and enable critical decision making. Responsibilities
will include evaluating and applying new statistical methodologies and/or
advanced study design to improve information quality and utility, and
enhance efficiency of clinical trials.

The candidate will have the opportunity to explore, learn and utilize
state-of-the-art methodologies to help shape our question-based product
development plans and aid in dose selection. The candidate will be
advising colleagues on statistical modelling and simulation methodologies. =

The candidate will be working across the GSK drug discovery pipeline from
pre-candidate selection through post-licensing within
therapeutically-aligned groups.

Qualification:

The candidate should have an extensive statistical modelling and
simulation skill set covering aspects of the following: Design and
analysis of Phase II/III clinical trials, Disease progression modelling,
Meta-data models utilising internal and external sources, Bayesian
Statistics, Decision Analysis and Clinical trial simulation

PhD in Statistics and/or Mathematics. A strong background in Bayesian
statistics is recommended.
Understanding of pharmacokinetics/dynamics and population modeling
methods.
Advanced awareness in optimal designs and adaptive designs.
Computer/software proficiency supporting data analysis, including
familiarity with R/S-Plus, BUGS, SAS and/or NONMEM.
Good written and oral communication skills
Knowledge of regulatory guidelines pertaining to drug development,
statistics and M&S
Team-oriented, self-motivated, innovative


If you are interested in this position please visit www.gsk.com/careers
quoting Req ID 54038.

If you want more information about the position please contact Roberto
Gomeni, Head Pharmacometrics: roberto.a.gomeni
Received on Mon Jun 01 2009 - 08:36:51 EDT

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