From: hoxu8507

Date: Wed, 03 Jun 2009 12:16:41 +1000

Dear Nonmem users,

I have been running a POPPK model with sparse sampling. This drug is

given intravenously and the half life is about 15 mins.

NONMEM VI run gives the following error:

forrtl: error (73): floating divide by zero

Image PC Routine

Line Source

nonmem1.exe 0040141C Unkown Unkown Unkown

.......

Estimation omitted

The control stream is as following:

$SUBR ADVAN1 TRANS2

$PK

TVCL=THETA(1)

TVV=THETA(2)

CL = TVCL*EXP(ETA(1)) ;CL

V = TVV*EXP(ETA(2)) ;V

S1 = V ;Scaling factor

$ERROR

Y=F*EXP(ERR(1))+ERR(2) ;EXPONENTIAL and additive residual

IPRED=F

IRES = DV - F

W = F

IF(W.EQ.0) W = 1

IWRES = IRES/W

$THETA

(0.1, 50) ;POPCL

(0.01, 13.89) ;POPV

$OMEGA

0.36 ;BSVCL

0.25 ;BSVV

$SIGMA

0.49 ; EXPONENTIAL portion

0.123 ; Additive portion

$ESTIMATION MAX=9990 SIG=3 PRINT=1 NOABORT POSTHOC

METHOD=COND INTER

$COVARIANCE MATRIX=S

Any suggestions would be highly appreciated. Thanks.

Dr. Hongmei Xu

Faculty of Pharmacy (A15)

University of Sydney, NSW 2006

Email: hongmei

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Received on Tue Jun 02 2009 - 22:16:41 EDT

Date: Wed, 03 Jun 2009 12:16:41 +1000

Dear Nonmem users,

I have been running a POPPK model with sparse sampling. This drug is

given intravenously and the half life is about 15 mins.

NONMEM VI run gives the following error:

forrtl: error (73): floating divide by zero

Image PC Routine

Line Source

nonmem1.exe 0040141C Unkown Unkown Unkown

.......

Estimation omitted

The control stream is as following:

$SUBR ADVAN1 TRANS2

$PK

TVCL=THETA(1)

TVV=THETA(2)

CL = TVCL*EXP(ETA(1)) ;CL

V = TVV*EXP(ETA(2)) ;V

S1 = V ;Scaling factor

$ERROR

Y=F*EXP(ERR(1))+ERR(2) ;EXPONENTIAL and additive residual

IPRED=F

IRES = DV - F

W = F

IF(W.EQ.0) W = 1

IWRES = IRES/W

$THETA

(0.1, 50) ;POPCL

(0.01, 13.89) ;POPV

$OMEGA

0.36 ;BSVCL

0.25 ;BSVV

$SIGMA

0.49 ; EXPONENTIAL portion

0.123 ; Additive portion

$ESTIMATION MAX=9990 SIG=3 PRINT=1 NOABORT POSTHOC

METHOD=COND INTER

$COVARIANCE MATRIX=S

Any suggestions would be highly appreciated. Thanks.

Dr. Hongmei Xu

Faculty of Pharmacy (A15)

University of Sydney, NSW 2006

Email: hongmei

----------------------------------------------------------------

This message was sent using IMP, the Internet Messaging Program.

Received on Tue Jun 02 2009 - 22:16:41 EDT