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Coding a triple absorption model

From: Samtani, Mahesh [PRDUS] <MSamtani>
Date: Thu, 4 Jun 2009 16:34:19 -0400

> Dear NMusers,
I am using a dual absorption model as follows (The dose is split into 2 =
fractions and the splitting fraction, THETA(.), is an estimated =
parameter in the model):

TPH = LOG(THETA(.)/(1-THETA(.)))
TH = EXP(TPH+ETA(.))/(1+EXP(TPH+ETA(.)))
F2 = TH
F1 = 1-TH

However, upon prolonged sampling we can observe a 3rd shallow phase. I =
would like to use a 3-depot absorption process with F1, F2 and =
F3=1-F1-F2. Both F1 and F2 need etas using some type of transformation =
such that neither one of them exceed 1 nor does their sum exceed 1. Can =
some one kindly provide the NONMEM code.

Thanking you in advance,
Mahesh


Received on Thu Jun 04 2009 - 16:34:19 EDT

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