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Subject: [NMusers] Coding a triple absorption model
From: Samtani, Mahesh [PRDUS] <MSamtani Date: Thu, June 04, 2009 4:34 pm
To: <nmusers
Coding a triple absorption model Dear NMusers,
I am using a dual absorption model as follows (The dose is split into 2 fr=
actions and the splitting fraction, THETA(.), is an estimated parameter in =
the model):
TPH ==
LOG(THETA(.)/(1-THETA(.)))
TH = EXP(TPH+ETA(.))/(1+EXP(TPH+ETA(.)))
F2 = TH
F1 = 1-TH
However, upon prolonged sampling we can observe a 3rd shallow ph=
ase. I would like to use a 3-depot absorption process with F1, F2 and F3==
1-F1-F2. Both F1 and F2 need etas using some type of transformation such th=
at neither one of them exceed 1 nor does their sum exceed 1. Can some one k=
indly provide the NONMEM code.
Thanking you in advance,
M=
ahesh