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10th Fisher/Shafer NONMEM/PLT Tools Workshop

From: Steven Shafer <steven.shafer>
Date: Mon, 8 Jun 2009 03:48:20 -0700

Dear Colleagues:


Every other year Dennis and I hold a NONMEM Workshop in Europe. This year we
will be holding the 10th Fisher/Shafer NONMEM/PLT Tools workshop in Basel,
Switzerland, from Tuesday, November 3rd through November 10th, 2009. You can
see the course description and registration details at


Our NONMEM Workshops are now in their 5th year. Dennis Fisher and I have
spent the past two years developing PLT Tools, which has now completed its
first year of testing. We introduced PLT Tools as the workshop platform for
the 9th Fisher/Shafer NONMEM course last month, giving participants in that
course access to bootstrap analysis, log-likelihood profiling, and jackknife
analysis, in addition to the outstanding diagnostic graphics from PLT Tools.


You can download the completely functional unlicensed version of PLT Tools
from Model validation is facilitated with automated
procedures for visual predictive checks, log likelihood profiling,
jack-knife analysis, and extensive bootstrap analysis for determination of
standard errors. PLT Tools also includes a robust library of control streams
and a control stream editor. CFR 11 Part 22 compliance is built into the
program, as is extensive run archiving and creation of audit trails. PLT
Tools also includes a comprehensive set of graphical and statistical
analyses facilitate model development and testing. A sample output can be
downloaded from


The licensed version of PLT Tools supports multiple simultaneous NONMEM
runs, which can substantially facilitate throughput on multicore computers.
A multiuser networked version of PLT Tools is also available. The multiuser
networked version can distribute NONMEM jobs across multiple networked


One of the joys of teaching this course is the considerable evolution in
course material every time the workshop is offered. Dennis and I continuous
update the course materials, based both on feedback from course participants
and our own exploration of novel pharmacometric problems. The feedback from
the 9th course indicated that PLT Tools was exceedingly well received, and
workshop participants appreciated their having access to these advanced and
powerful tools.


Dennis and I hope to see you in Basel!




Steven L. Shafer, MD

Professor of Anesthesiology, Columbia University

Adjunct Professor of Anesthesia, Stanford University

Adjunct Professor of Biopharmaceutical Sciences, UCSF

Editor-in-Chief, Anesthesia & Analgesia



Received on Mon Jun 08 2009 - 06:48:20 EDT

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