NONMEM Users Network Archive

Hosted by Cognigen

Re: Census 1.1 beta released

From: Justin Wilkins <justinwil>
Date: Tue, 9 Jun 2009 23:31:29 +0200

Dear Carlos,

This warning is triggered when relative standard errors on a parameter
exceed a user-supplied limit. These limits can be specified in the "General=
"
tab of the Options dialog, for THETA, OMEGA and SIGMA parameters (which hav=
e
defaults of 0.3, 0.5 and 0.5, respectively).

This actually qualifies as a bug report, since I notice that the limit
options are incorrectly labelled as "% Coefficient of variation".

"Solving" them might be non-straightforward, and is fundamentally a
model-building issue - large standard errors are associated with parameters
that are poorly estimated, and may indicate potential overparameterization
or model misspecification. Without knowing details of the model in question=
,
it's difficult to be much more specific, but in general it's helpful to try
dropping poorly estimated parameters from the model one at a time to assess
the impact of doing so on the the other parameter estimates, the objective
function value and the diagnostic plots. If such effects are negligible, th=
e
poorly-estimated parameter is probably not needed.

Best
Justin

2009/6/9 Carlos Hoyo <citocromo

> Dear Justin,
> How to solve the "Large SEs" reported by Census?
>
> Saludos,
>
> --
>
> Dr. Carlos Hoyo Vadillo
> Sec. Ext. Farmacología
> Cinvestav
> Av. IPN 2508
> San Pedro Zacatenco
> 07360 México DF
>
> Tel: +52-55-5061-3800 ext 5438
> Cel. 55-385 22 888
>
> citocromo
>
>
>
>
>
>
>
>
> On Jun 2, 2009, at 5:09 AM, Justin Wilkins wrote:
>
> Dear Carlos,
>
> In principle, porting to other platforms is a wonderful idea, but current=
ly
> time constraints and the dependence of Delphi on Windows make this
> impossible for a one-man spare-time development team like myself in the
> short term. Of course, the source code is freely available - and if someo=
ne
> would like to give this a go in something like Lazarus (the cross-platfor=
m
> Free Pascal environment) or, even better, create a C++ implementation usi=
ng
> something like Qt, that would be wonderful...
>
> Best regards
> Justin
>
> 2009/5/26 Carlos Hoyo <citocromo
>
>> Dear Justin,
>> Plans for a Mac Os or linux version?
>>
>> Saludos,
>>
>> --
>>
>> Dr. Carlos Hoyo Vadillo
>> Sec. Ext. Farmacología
>> Cinvestav
>> Av. IPN 2508
>> San Pedro Zacatenco
>> 07360 México DF
>>
>> Tel: +52-55-5061-3800 ext 5438
>> Cel. 55-385 22 888
>>
>> citocromo
>>
>>
>>
>>
>>
>>
>>
>>
>> On May 17, 2009, at 6:10 PM, Justin Wilkins wrote:
>>
>> Dear all,
>>
>> Census 1.1 has been released to beta. This version includes a number of
>> enhancements:
>>
>> * The R(D)COM library has been removed, fixing some nasty
>> incompatibilities with R version 2.8.0 and above (affecting Xpose plotti=
ng).
>> It has been replaced with R-based file output, including support for PDF=
,
>> JPG, PNG, BMP, Postscript and Xfig formats. Files have the additional
>> advantage of being retained after the plot window is closed.
>> * An R interaction layer and console window, controlled by a taskbar
>> button, has been added.
>> * MD5 file fingerprints are now optionally collected for NONMEM input an=
d
>> output, and checked for changes whenever accessed within Census.
>>
>> You can get it from http://census.sourceforge.net/, as usual. Comments,
>> suggestions, support requests, bug reports and the like are as always ve=
ry
>> welcome, and can be sent to the Census mailing list - registration is
>> provided at http://census.sourceforge.net/docs.htm.
>>
>> Census is a comprehensive project manager for NONMEM, providing detailed
>> summary, comparison and overview of the runs comprising a given project,
>> including the display of output data, post-run processing, and rapid
>> diagnostic plots through tight integration with Xpose. While it runs onl=
y
>> under Windows, it can read any NONMEM output to which Windows has access=
 to
>> via drive mapping.
>>
>> Census is, and will remain, free software under the Mozilla Public
>> License, version 1.1.
>>
>> Last but not least, while this is a stable release, it's still technical=
ly
>> a beta, incorporating a brand new backend, and it has not been as rigoro=
usly
>> tested as a full release might be. Please bear this in mind before delet=
ing
>> your old versions of the software...
>>
>> Best
>> Justin
>>
>> --
>> Justin Wilkins
>> -----------------------------
>> Colmarerstrasse 31
>> 4055 Basel
>> Switzerland
>> -----------------------------
>> Email: justinwil
>> Skype: kestrel_za2002
>> Mobile: +41 76 561 0949
>>
>>
>>
>
>
> --
> Justin Wilkins
> -----------------------------
> Colmarerstrasse 31
> 4055 Basel
> Switzerland
> -----------------------------
> Email: justinwil
> Skype: kestrel_za2002
> Mobile: +41 76 561 0949
>
>
>


--
Justin Wilkins
-----------------------------
Colmarerstrasse 31
4055 Basel
Switzerland
-----------------------------
Email: justinwil
Skype: kestrel_za2002
Mobile: +41 76 561 0949

Received on Tue Jun 09 2009 - 17:31:29 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.