NONMEM Users Network Archive

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Re: Problem with HESSIAN

From: Leonid Gibiansky <LGibiansky>
Date: Mon, 29 Jun 2009 07:31:20 -0400

DEL part is not needed (unless you do log-transform; and even then,
there are better methods).
Try TOL=8 and/or ADVAN8 ADVAN9


Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
e-mail: LGibiansky at
tel: (301) 767 5566

Brogren, Jacob wrote:
> Hi, thank's for the advice. Unfortunately neither "DEL=0.01" nor "S3=V3" resolved the issue. I've also tried log-transforming both sides with no improvement.
> Regards
> Jacob
Received on Mon Jun 29 2009 - 07:31:20 EDT

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